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• W2079509436 abstract "The early biological response at titanium (Ti), copper (Cu)-coated Ti and sham sites was evaluated in an in vivo rat model. Material surface chemical and topographical properties were characterized using Auger electron spectroscopy, energy dispersive X-ray spectroscopy and interferometry, respectively. The number of leukocytes, cell types and cell viability (release of lactate dehydrogenase) were determined in the implant-interface exudate. The contents of activated nuclear transcription factor NF-κB, interleukin-6 (IL-6) and interleukin-10 (IL-10) were determined by enzyme linked immunosorbent assay. An increase in the number of leukocytes, in particular, polymorphonuclear leukocytes, was observed between 12 and 48 h around Cu. A marked decrease of exudate cell viability was found around Cu after 48 h. The total amounts of activated NF-κB after 12 h was highest in Ti exudates whereas after 48 h the highest amount of NF-κB was detected around Cu. The levels of cytokine IL-6 were consistently high around Cu at both time periods. No differences in IL-10 contents were detected, irrespective of material/sham and time. The results show that materials with different toxicity grades (titanium with low and copper with high toxicity) exhibit early differences in the activation of NF-κB, extracellular expression and secretion of mediators, causing major differences in inflammatory cell accumulation and death in vivo." @default.
• W2079509436 created "2016-06-24" @default.
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• W2079509436 date "2005-02-01" @default.
• W2079509436 modified "2023-10-18" @default.
• W2079509436 title "In vivo cytokine secretion and NF-κB activation around titanium and copper implants" @default.
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• W2079509436 doi "https://doi.org/10.1016/j.biomaterials.2004.02.066" @default.
• W2079509436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15276360" @default.
• W2079509436 hasPublicationYear "2005" @default.
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