FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079519119> ?p ?o ?g. }

• W2079519119 endingPage "7665" @default.
• W2079519119 startingPage "7661" @default.
• W2079519119 abstract "An approach for high-spatial-resolution mapping of functional circuitry in living mammalian brain slices has been developed. The locations of neurons making functional synaptic connections to a single neuron are revealed by photostimulation of highly restricted areas of the slice (50-100 microns in diameter) while maintaining a whole-cell recording of the neuron of interest. Photostimulation is achieved by bathing brain slices in a molecularly caged form of the neurotransmitter glutamate [L-glutamic acid alpha-(4,5-dimethoxy-2-nitrobenzyl) ester], which is then converted to the active form by brief pulses (< 1 ms in duration) of ultraviolet irradiation. Direct activation of receptors on recorded neurons in rat hippocampus and ferret visual cortex demonstrates that photostimulation is reliable and reproducible and can be repeated at the same site at least 30 times without obvious decrement in neuronal responsiveness. Photostimulation of presynaptic neurons at sites distant to the recorded neuron evoked synaptic responses in hippocampal and cortical cells at distances of up to several millimeters from the recorded neuron. Stimulation of 25-100 distinct presynaptic sites while recording from a single postsynaptic neuron was easily achieved. Caged glutamate-based photostimulation eliminates artifacts and limitations inherent in conventional stimulation methods, including stimulation of axons of passage, desensitization, and poor temporal resolution of puffer pipettes, and current artifacts of iontophoretic application. This approach allows detailed physiological investigation and manipulation of the complex intrinsic circuitry of the mammalian brain." @default.
• W2079519119 created "2016-06-24" @default.
• W2079519119 creator A5061630723 @default.
• W2079519119 creator A5063751572 @default.
• W2079519119 date "1993-08-15" @default.
• W2079519119 modified "2023-10-16" @default.
• W2079519119 title "Photostimulation using caged glutamate reveals functional circuitry in living brain slices." @default.
• W2079519119 cites W1780057589 @default.
• W2079519119 cites W1864836097 @default.
• W2079519119 cites W1965504075 @default.
• W2079519119 cites W1966269034 @default.
• W2079519119 cites W2043985651 @default.
• W2079519119 cites W2046384002 @default.
• W2079519119 cites W2056934252 @default.
• W2079519119 cites W2059939266 @default.
• W2079519119 cites W2062820369 @default.
• W2079519119 cites W2071247419 @default.
• W2079519119 cites W2084385479 @default.
• W2079519119 cites W2099834228 @default.
• W2079519119 cites W2106498256 @default.
• W2079519119 cites W2108875213 @default.
• W2079519119 cites W2127457386 @default.
• W2079519119 cites W2130198059 @default.
• W2079519119 cites W2155969495 @default.
• W2079519119 cites W2248888640 @default.
• W2079519119 cites W2406265206 @default.
• W2079519119 cites W2415806768 @default.
• W2079519119 cites W4238793555 @default.
• W2079519119 doi "https://doi.org/10.1073/pnas.90.16.7661" @default.
• W2079519119 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47202" @default.
• W2079519119 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7689225" @default.
• W2079519119 hasPublicationYear "1993" @default.
• W2079519119 type Work @default.
• W2079519119 sameAs 2079519119 @default.
• W2079519119 citedByCount "367" @default.
• W2079519119 countsByYear W20795191192012 @default.
• W2079519119 countsByYear W20795191192013 @default.
• W2079519119 countsByYear W20795191192014 @default.
• W2079519119 countsByYear W20795191192015 @default.
• W2079519119 countsByYear W20795191192016 @default.
• W2079519119 countsByYear W20795191192017 @default.
• W2079519119 countsByYear W20795191192018 @default.
• W2079519119 countsByYear W20795191192019 @default.
• W2079519119 countsByYear W20795191192020 @default.
• W2079519119 countsByYear W20795191192021 @default.
• W2079519119 countsByYear W20795191192022 @default.
• W2079519119 countsByYear W20795191192023 @default.
• W2079519119 crossrefType "journal-article" @default.
• W2079519119 hasAuthorship W2079519119A5061630723 @default.
• W2079519119 hasAuthorship W2079519119A5063751572 @default.
• W2079519119 hasBestOaLocation W20795191191 @default.
• W2079519119 hasConcept C12554922 @default.
• W2079519119 hasConcept C169760540 @default.
• W2079519119 hasConcept C170493617 @default.
• W2079519119 hasConcept C185263204 @default.
• W2079519119 hasConcept C185592680 @default.
• W2079519119 hasConcept C197341189 @default.
• W2079519119 hasConcept C24998067 @default.
• W2079519119 hasConcept C2778794669 @default.
• W2079519119 hasConcept C2781151714 @default.
• W2079519119 hasConcept C2781161787 @default.
• W2079519119 hasConcept C29694410 @default.
• W2079519119 hasConcept C55493867 @default.
• W2079519119 hasConcept C61174792 @default.
• W2079519119 hasConcept C86803240 @default.
• W2079519119 hasConceptScore W2079519119C12554922 @default.
• W2079519119 hasConceptScore W2079519119C169760540 @default.
• W2079519119 hasConceptScore W2079519119C170493617 @default.
• W2079519119 hasConceptScore W2079519119C185263204 @default.
• W2079519119 hasConceptScore W2079519119C185592680 @default.
• W2079519119 hasConceptScore W2079519119C197341189 @default.
• W2079519119 hasConceptScore W2079519119C24998067 @default.
• W2079519119 hasConceptScore W2079519119C2778794669 @default.
• W2079519119 hasConceptScore W2079519119C2781151714 @default.
• W2079519119 hasConceptScore W2079519119C2781161787 @default.
• W2079519119 hasConceptScore W2079519119C29694410 @default.
• W2079519119 hasConceptScore W2079519119C55493867 @default.
• W2079519119 hasConceptScore W2079519119C61174792 @default.
• W2079519119 hasConceptScore W2079519119C86803240 @default.
• W2079519119 hasIssue "16" @default.
• W2079519119 hasLocation W20795191191 @default.
• W2079519119 hasLocation W20795191192 @default.
• W2079519119 hasLocation W20795191193 @default.
• W2079519119 hasLocation W20795191194 @default.
• W2079519119 hasOpenAccess W2079519119 @default.
• W2079519119 hasPrimaryLocation W20795191191 @default.
• W2079519119 hasRelatedWork W122087398 @default.
• W2079519119 hasRelatedWork W1941392759 @default.
• W2079519119 hasRelatedWork W2097921303 @default.
• W2079519119 hasRelatedWork W2479745712 @default.
• W2079519119 hasRelatedWork W2529475745 @default.
• W2079519119 hasRelatedWork W2904814909 @default.
• W2079519119 hasRelatedWork W2974177916 @default.
• W2079519119 hasRelatedWork W3085053449 @default.
• W2079519119 hasRelatedWork W4298691647 @default.
• W2079519119 hasRelatedWork W4301690486 @default.
• W2079519119 hasVolume "90" @default.
• W2079519119 isParatext "false" @default.

• next