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• W2079521844 abstract "The calcitonin (CT)-like (CL) receptor is a CT gene-related peptide (CGRP) receptor or an adrenomedullin (AM) receptor when co-expressed with receptor-activity-modifying proteins (RAMP) 1 or 2, respectively. The CL receptor shows 57% overall sequence identity with the CT receptor, but the homology is much lower in the extreme N-terminus. An N-terminal deletion mutant of the human (h) CL receptor (Delta18-hCL) and a chimeric receptor consisting of the N-terminal amino acids of the porcine (p) CT receptor fused to the Delta18-hCL receptor (pCT-hCL) were therefore analyzed. The Delta18-hCL receptor function was abolished when co-expressed with RAMP1 or -2. The pCT-hCL receptor was a fully functional CGRP receptor when co-expressed with RAMP1, but the RAMP2-dependent AM receptor function was impaired. Limited sequence similarities in the N-terminus of the pCT and the hCL receptors rescue CGRP but not AM receptor binding and signalling." @default.
• W2079521844 created "2016-06-24" @default.
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• W2079521844 date "2002-10-24" @default.
• W2079521844 modified "2023-10-15" @default.
• W2079521844 title "The extreme N‐terminus of the calcitonin‐like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene‐related peptide" @default.
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• W2079521844 doi "https://doi.org/10.1016/s0014-5793(02)03585-8" @default.
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