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• W2079525073 abstract "Abstract The ultrastructural alterations caused by temporary ischemia have been studied in liver parenchymal cells of fasted and fed rats. Ischemia was induced by ligation or clamping of the liver pedicle. Samples of liver were taken 15, 30, 60, and 120 minutes after ligation, and also 2 hours after the re-establishment of blood circulation in the liver lobes after previous ischemia. The first alterations caused by ischemia are changes in the plasma membrane, with disappearance of the microvilli at the sinusoidal border, formation of a number of vacuoles in the sinusoidal region, and disappearance of the intramitochondrial dense granules. By prolonging the duration of ischemia, mitochondria swell, the endoplasmic reticulum becomes fragmented and dilated, the microvilli of the bile canaliculi become swollen and greatly distorted, and the number of microbodies increases. In fasted animals these alterations appear earlier than in fed animals. All these changes are reversible if the duration of ischemia is not longer than 60 minutes; 2 hours after the re-establishment of blood circulation the cells have regained their normal appearance. But if ischemia lasts 120 minutes, the cells lose their capacity of recovery, and 2 hours after the re-establishment of blood circulation most of them are verging on necrosis. No specific lesion appears in relation to the death of liver cells subjected to ischemia. The limit of irreversibility is reached through a progressive deterioration of different cellular structures, and death appears as the outcome of many defects in subcellular organization that have passed the stage of compensatory repair." @default.
• W2079525073 created "2016-06-24" @default.
• W2079525073 creator A5060841874 @default.
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• W2079525073 date "1964-08-01" @default.
• W2079525073 modified "2023-09-22" @default.
• W2079525073 title "Ultrastructural cytoplasmic changes of liver cells after reversible and irreversible ischemia" @default.
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• W2079525073 doi "https://doi.org/10.1016/0014-4800(64)90006-1" @default.
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