FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079530056> ?p ?o ?g. }

• W2079530056 endingPage "94" @default.
• W2079530056 startingPage "85" @default.
• W2079530056 abstract "Cystic fibrosis is associated with mutations of the cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-regulated plasma membrane chloride channel. Cystic fibrosis patients have been reported to possess elevated sulfation of glycoconjugates, which may contribute to the pathogenesis of the disease. Sulfation of glycosaminoglycans by a cystic fibrosis pancreatic adenocarcinoma cell line homozygous for DeltaF508 (CFPAC-1), a control pancreatic cell line (PANC-1), two CFPAC-1 cell lines transfected with the gene for CFTR (PLJ-CFTR-4.7, TR20), and a mock-transfected CFPAC-1 control (PLJ-6) was investigated. Cells were radiolabeled with [35S]sulfate and [3H]glucosamine, and glycosaminoglycans secreted into the medium after 24 and 72 h were isolated. Chondroitinase ABC digestion of chondroitin/dermatan sulfate allowed the recovery of disaccharides which were analyzed for their degree of sulfation by strong anion-exchange HPLC. No differences in the extent of sulfation by any of the cell lines were noted. However, glycoaminoglycans synthesized by cystic fibrosis cells consistently exhibited twofold higher [35S]-sulfate:[3H]glucosamine ratios than the controls. We conclude that CFTR plays no role in the sulfation of chondroitin/dermatan sulfate by pancreatic cells and that isotope incorporation ratios alone are insufficient evidence of changes in sulfation levels." @default.
• W2079530056 created "2016-06-24" @default.
• W2079530056 creator A5022486673 @default.
• W2079530056 creator A5079677641 @default.
• W2079530056 creator A5080419846 @default.
• W2079530056 creator A5087929660 @default.
• W2079530056 date "1997-10-01" @default.
• W2079530056 modified "2023-09-25" @default.
• W2079530056 title "Sulfation of Chondroitin/Dermatan Sulfate by Cystic Fibrosis Pancreatic Duct Cells Is Not Different from Control Cells" @default.
• W2079530056 cites W1559464451 @default.
• W2079530056 cites W1562906663 @default.
• W2079530056 cites W1611708000 @default.
• W2079530056 cites W1791314931 @default.
• W2079530056 cites W1869966160 @default.
• W2079530056 cites W1976248923 @default.
• W2079530056 cites W1983222956 @default.
• W2079530056 cites W1988762156 @default.
• W2079530056 cites W1995240556 @default.
• W2079530056 cites W2028171116 @default.
• W2079530056 cites W2031727901 @default.
• W2079530056 cites W2033969190 @default.
• W2079530056 cites W2041420763 @default.
• W2079530056 cites W2053700253 @default.
• W2079530056 cites W2062578427 @default.
• W2079530056 cites W2070457962 @default.
• W2079530056 cites W2075390708 @default.
• W2079530056 cites W2077264898 @default.
• W2079530056 cites W2080856635 @default.
• W2079530056 cites W2129391213 @default.
• W2079530056 cites W2141365582 @default.
• W2079530056 cites W2147286631 @default.
• W2079530056 cites W2147839947 @default.
• W2079530056 cites W2151134543 @default.
• W2079530056 cites W2266521079 @default.
• W2079530056 cites W2429848542 @default.
• W2079530056 cites W4232534952 @default.
• W2079530056 cites W4300573843 @default.
• W2079530056 cites W98281195 @default.
• W2079530056 doi "https://doi.org/10.1006/bmme.1997.2625" @default.
• W2079530056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9367803" @default.
• W2079530056 hasPublicationYear "1997" @default.
• W2079530056 type Work @default.
• W2079530056 sameAs 2079530056 @default.
• W2079530056 citedByCount "5" @default.
• W2079530056 countsByYear W20795300562012 @default.
• W2079530056 crossrefType "journal-article" @default.
• W2079530056 hasAuthorship W2079530056A5022486673 @default.
• W2079530056 hasAuthorship W2079530056A5079677641 @default.
• W2079530056 hasAuthorship W2079530056A5080419846 @default.
• W2079530056 hasAuthorship W2079530056A5087929660 @default.
• W2079530056 hasConcept C104317684 @default.
• W2079530056 hasConcept C126322002 @default.
• W2079530056 hasConcept C134018914 @default.
• W2079530056 hasConcept C153074725 @default.
• W2079530056 hasConcept C155138218 @default.
• W2079530056 hasConcept C185592680 @default.
• W2079530056 hasConcept C2776735749 @default.
• W2079530056 hasConcept C2776938444 @default.
• W2079530056 hasConcept C2778066728 @default.
• W2079530056 hasConcept C2778125326 @default.
• W2079530056 hasConcept C2779553658 @default.
• W2079530056 hasConcept C54009773 @default.
• W2079530056 hasConcept C54355233 @default.
• W2079530056 hasConcept C55493867 @default.
• W2079530056 hasConcept C71924100 @default.
• W2079530056 hasConcept C81885089 @default.
• W2079530056 hasConcept C86803240 @default.
• W2079530056 hasConceptScore W2079530056C104317684 @default.
• W2079530056 hasConceptScore W2079530056C126322002 @default.
• W2079530056 hasConceptScore W2079530056C134018914 @default.
• W2079530056 hasConceptScore W2079530056C153074725 @default.
• W2079530056 hasConceptScore W2079530056C155138218 @default.
• W2079530056 hasConceptScore W2079530056C185592680 @default.
• W2079530056 hasConceptScore W2079530056C2776735749 @default.
• W2079530056 hasConceptScore W2079530056C2776938444 @default.
• W2079530056 hasConceptScore W2079530056C2778066728 @default.
• W2079530056 hasConceptScore W2079530056C2778125326 @default.
• W2079530056 hasConceptScore W2079530056C2779553658 @default.
• W2079530056 hasConceptScore W2079530056C54009773 @default.
• W2079530056 hasConceptScore W2079530056C54355233 @default.
• W2079530056 hasConceptScore W2079530056C55493867 @default.
• W2079530056 hasConceptScore W2079530056C71924100 @default.
• W2079530056 hasConceptScore W2079530056C81885089 @default.
• W2079530056 hasConceptScore W2079530056C86803240 @default.
• W2079530056 hasIssue "1" @default.
• W2079530056 hasLocation W20795300561 @default.
• W2079530056 hasLocation W20795300562 @default.
• W2079530056 hasOpenAccess W2079530056 @default.
• W2079530056 hasPrimaryLocation W20795300561 @default.
• W2079530056 hasRelatedWork W1518072671 @default.
• W2079530056 hasRelatedWork W1997183674 @default.
• W2079530056 hasRelatedWork W2010669038 @default.
• W2079530056 hasRelatedWork W2045155926 @default.
• W2079530056 hasRelatedWork W2064278177 @default.
• W2079530056 hasRelatedWork W2318643881 @default.
• W2079530056 hasRelatedWork W2330819842 @default.
• W2079530056 hasRelatedWork W2414975270 @default.
• W2079530056 hasRelatedWork W2473177597 @default.

• next