Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079530060> ?p ?o ?g. }
- W2079530060 endingPage "4039" @default.
- W2079530060 startingPage "4034" @default.
- W2079530060 abstract "To investigate the significance of isolated hepatitis B core antibody (anti-HBc) and to analyze the response to hepatitis B virus (HBV) booster vaccination in young adults with isolated anti-HBc who had been fully vaccinated with HBV vaccine as infants. We screened 1734 new university entrants who had been fully vaccinated against HBV in infancy for the presence of hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), and anti-HBc upon university entry. Results positive for isolated anti-HBc were reconfirmed by testing for the presence of HBsAg and anti-HBc once more, and further evaluated for anti-HCV, anti-HIV, and HBV DNA status 6 months later. Students were also offered HBV booster vaccinations at that time. Geometric mean titers (GMT) of anti-HBs after one booster dose of HBV were compared between students with isolated anti-HBc and students with HBV naïve status. The overall prevalence of isolated anti-HBc in our student cohort was 1.2% (21 of 1734). No evidence of occult HBV infection was observed. A “booster” anamnestic response (anti-HBs titer ≥10 mIU/mL) was noted in 95% (20 of 21) of subjects with isolated anti-HBc. After re-measurement of anti-HBc, 13 (62%) of the 21 subjects with isolated anti-HBc were reclassified as having resolved HBV infection with a loss of anti-HBs. In the remaining 8 subjects (38%), isolated anti-HBc was determined to be false positive. The HBV status of these 8 subjects was HBV naïve due to the waning-off effect of anti-HBs of the neonatal HBV vaccination. There was no significant difference in anamnestic response to a single HBV booster dose of vaccine between students with isolated anti-HBc (n = 13) and those with HBV naïve (n = 323) status (GMT 50.6 vs 47.7 mIU/mL, P = 0.90). The presence of isolated anti-HBc 18 years after HBV vaccination can be attributed to post-HBV infection with a loss of anti-HBs and to a decline in anti-HBs elicited by vaccine. A single HBV booster dose of vaccine is recommended for subjects with isolated anti-HBc who were fully vaccinated with HBV vaccine as infants. This finding needs to be replicated in further studies with larger cohorts." @default.
- W2079530060 created "2016-06-24" @default.
- W2079530060 creator A5001865399 @default.
- W2079530060 creator A5010804270 @default.
- W2079530060 creator A5011965402 @default.
- W2079530060 creator A5034083957 @default.
- W2079530060 creator A5056495977 @default.
- W2079530060 creator A5086495456 @default.
- W2079530060 date "2012-06-01" @default.
- W2079530060 modified "2023-09-23" @default.
- W2079530060 title "Significance and anamnestic response in isolated hepatitis B core antibody-positive individuals 18 years after neonatal hepatitis B virus vaccination in Taiwan" @default.
- W2079530060 cites W1548822778 @default.
- W2079530060 cites W1843203177 @default.
- W2079530060 cites W1964727866 @default.
- W2079530060 cites W1972064394 @default.
- W2079530060 cites W1975184667 @default.
- W2079530060 cites W1984458316 @default.
- W2079530060 cites W1990376031 @default.
- W2079530060 cites W1997155721 @default.
- W2079530060 cites W2001599011 @default.
- W2079530060 cites W2001748255 @default.
- W2079530060 cites W2010132108 @default.
- W2079530060 cites W2012324894 @default.
- W2079530060 cites W2023839011 @default.
- W2079530060 cites W2031698845 @default.
- W2079530060 cites W2046053558 @default.
- W2079530060 cites W2051586219 @default.
- W2079530060 cites W2058745613 @default.
- W2079530060 cites W2080104847 @default.
- W2079530060 cites W2096996627 @default.
- W2079530060 cites W2097296715 @default.
- W2079530060 cites W2098740893 @default.
- W2079530060 cites W2108498132 @default.
- W2079530060 cites W2115315647 @default.
- W2079530060 cites W2117941833 @default.
- W2079530060 cites W2126893086 @default.
- W2079530060 cites W2136413995 @default.
- W2079530060 cites W2140492080 @default.
- W2079530060 cites W2150141117 @default.
- W2079530060 cites W2152024365 @default.
- W2079530060 cites W2157309419 @default.
- W2079530060 cites W2162798589 @default.
- W2079530060 cites W2171697238 @default.
- W2079530060 cites W2322310797 @default.
- W2079530060 cites W328946950 @default.
- W2079530060 cites W4293661848 @default.
- W2079530060 doi "https://doi.org/10.1016/j.vaccine.2012.04.031" @default.
- W2079530060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22531558" @default.
- W2079530060 hasPublicationYear "2012" @default.
- W2079530060 type Work @default.
- W2079530060 sameAs 2079530060 @default.
- W2079530060 citedByCount "23" @default.
- W2079530060 countsByYear W20795300602013 @default.
- W2079530060 countsByYear W20795300602014 @default.
- W2079530060 countsByYear W20795300602015 @default.
- W2079530060 countsByYear W20795300602016 @default.
- W2079530060 countsByYear W20795300602017 @default.
- W2079530060 countsByYear W20795300602018 @default.
- W2079530060 countsByYear W20795300602021 @default.
- W2079530060 countsByYear W20795300602023 @default.
- W2079530060 crossrefType "journal-article" @default.
- W2079530060 hasAuthorship W2079530060A5001865399 @default.
- W2079530060 hasAuthorship W2079530060A5010804270 @default.
- W2079530060 hasAuthorship W2079530060A5011965402 @default.
- W2079530060 hasAuthorship W2079530060A5034083957 @default.
- W2079530060 hasAuthorship W2079530060A5056495977 @default.
- W2079530060 hasAuthorship W2079530060A5086495456 @default.
- W2079530060 hasConcept C12590561 @default.
- W2079530060 hasConcept C147483822 @default.
- W2079530060 hasConcept C159047783 @default.
- W2079530060 hasConcept C159654299 @default.
- W2079530060 hasConcept C203014093 @default.
- W2079530060 hasConcept C22070199 @default.
- W2079530060 hasConcept C2522874641 @default.
- W2079530060 hasConcept C2777382497 @default.
- W2079530060 hasConcept C2777410769 @default.
- W2079530060 hasConcept C2778600374 @default.
- W2079530060 hasConcept C2780593183 @default.
- W2079530060 hasConcept C32611913 @default.
- W2079530060 hasConcept C71924100 @default.
- W2079530060 hasConceptScore W2079530060C12590561 @default.
- W2079530060 hasConceptScore W2079530060C147483822 @default.
- W2079530060 hasConceptScore W2079530060C159047783 @default.
- W2079530060 hasConceptScore W2079530060C159654299 @default.
- W2079530060 hasConceptScore W2079530060C203014093 @default.
- W2079530060 hasConceptScore W2079530060C22070199 @default.
- W2079530060 hasConceptScore W2079530060C2522874641 @default.
- W2079530060 hasConceptScore W2079530060C2777382497 @default.
- W2079530060 hasConceptScore W2079530060C2777410769 @default.
- W2079530060 hasConceptScore W2079530060C2778600374 @default.
- W2079530060 hasConceptScore W2079530060C2780593183 @default.
- W2079530060 hasConceptScore W2079530060C32611913 @default.
- W2079530060 hasConceptScore W2079530060C71924100 @default.
- W2079530060 hasIssue "27" @default.
- W2079530060 hasLocation W20795300601 @default.
- W2079530060 hasLocation W20795300602 @default.
- W2079530060 hasOpenAccess W2079530060 @default.
- W2079530060 hasPrimaryLocation W20795300601 @default.