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• W2079532743 abstract "Currently available anticoagulants are limited by modest therapeutic benefits, narrow clinical applications, increased bleeding risk, and drug-induced thrombophilia. Because factor IX plays a pivotal role in tissue factor (TF)–mediated thrombin generation, it may represent a promising target for drug development. Several methods of attenuating factor IX activity, including monoclonal antibodies, synthetic active site-blocked competitive inhibitors, oral inhibitors, and RNA aptamers, have undergone investigation. This review summarizes present knowledge of factor IX inhibitors with emphasis on biology, pharmacology, preclinical data, and early-phase clinical experience in humans." @default.
• W2079532743 created "2016-06-24" @default.
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• W2079532743 date "2007-04-01" @default.
• W2079532743 modified "2023-10-04" @default.
• W2079532743 title "Factor IXa Inhibitors as Novel Anticoagulants" @default.
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• W2079532743 doi "https://doi.org/10.1161/01.atv.0000259363.91070.f1" @default.
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