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• W2079540794 abstract "Aim: Asymmetric dimethylarginine(ADMA) has recently been investigated as a risk marker for cardio- and cerebrovascular diseases. However, it is not currently known whether the ADMA levels are related to the risk of stroke in Japanese women. Methods: We examined 192 Japanese women(mean age, 55±9 years, range, 40-80 years) who underwent health examinations. The ADMA level and various vascular risk factors of each subject were assessed, and the predicted 10-year stroke risk was calculated using the point-based prediction model provided by the Japan Public Health Center study. Results: In a correlation coefficient analysis, age was found to be the only factor significantly correlated with the ADMA level. A significant odds ratio (OR) for a high predicted stroke risk(10-year risk, ≥5%) was noted in the highest ADMA level tertile(6.24; 95% CI, 1.13-34.5; p=0.036) compared with the lowest tertile, after adjusting for potential confounding factors. A significant OR for a high predicted stroke risk was also found for each increment in the ADMA tertile and standard deviation(adjusted OR, 2.42; 95% CI, 1.09-5.34; p=0.029; and 2.51; 95% CI, 1.24-5.11; p=0.011, respectively). Conclusions: An elevated ADMA level is significantly associated with an increased predicted stroke risk, suggesting that measuring the ADMA level is useful for identifying Japanese women with an elevated stroke risk." @default.
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• W2079540794 date "2014-01-01" @default.
• W2079540794 modified "2023-10-16" @default.
• W2079540794 title "The Asymmetric Dimethylarginine Level is Associated with the Predicted Stroke Risk in Japanese Women" @default.
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• W2079540794 doi "https://doi.org/10.5551/jat.22582" @default.
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