Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079542864> ?p ?o ?g. }
- W2079542864 endingPage "n/a" @default.
- W2079542864 startingPage "n/a" @default.
- W2079542864 abstract "The aim of this study was to compare angiogenesis and osteogenesis occurring within 8.0 mm diaphyseal defects created in canine tibiae treated using autograft or a biodegradable bone scaffold. All tibiae were reamed to 7.0 mm and fixed with a 6.5-mm statically locked intramedullary nail. Each of the 18 canines as allotted to one of three treatment groups: (1) left empty (N = 5), (2) treated with iliac crest autograft (N = 6), or (3) treated with a PLGA/calcium phosphate biodegradable scaffold (N = 7). Fluorescent markers were given at successive time periods: calcein green at 6 weeks, xylenol orange at 9 weeks, and tetracycline at 11 and 14 weeks. Animals were sacrificed at 15 weeks and their legs were perfused with a radio opaque compound. Samples were analyzed using Micro CT, bright-field microscopy and fluorescent microscopy. Scaffold samples were found to have significantly greater bone formation (p = 0.015) and blood vessel formation (p < 0.001) at their osteotomy sites than autograft samples. Bone formation rate in the periosteum was significantly greater in the autograft samples than the scaffold samples for all time periods. Bone formation at the osteotomy site was found to be significantly greater when associated with greater blood vessel formation (p = 0.026). The PLGA/calcium phosphate biodegradable scaffold we have employed supports angiogenesis within a segmental tibial defect that has adequate soft tissue coverage. © 2009 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:474–480, 2010" @default.
- W2079542864 created "2016-06-24" @default.
- W2079542864 creator A5036708179 @default.
- W2079542864 creator A5068946700 @default.
- W2079542864 creator A5086444103 @default.
- W2079542864 date "2009-01-01" @default.
- W2079542864 modified "2023-10-14" @default.
- W2079542864 title "A biodegradable scaffold for the treatment of a diaphyseal bone defect of the tibia" @default.
- W2079542864 cites W1897577213 @default.
- W2079542864 cites W1976739921 @default.
- W2079542864 cites W1994341340 @default.
- W2079542864 cites W2003654870 @default.
- W2079542864 cites W2006239006 @default.
- W2079542864 cites W2025788943 @default.
- W2079542864 cites W2035408362 @default.
- W2079542864 cites W2038013047 @default.
- W2079542864 cites W2055389372 @default.
- W2079542864 cites W2062278482 @default.
- W2079542864 cites W2068379178 @default.
- W2079542864 cites W2070464211 @default.
- W2079542864 cites W2072905377 @default.
- W2079542864 cites W2074380747 @default.
- W2079542864 cites W2075782445 @default.
- W2079542864 cites W2078450830 @default.
- W2079542864 cites W2080642797 @default.
- W2079542864 cites W2081914477 @default.
- W2079542864 cites W2087381462 @default.
- W2079542864 cites W2089360282 @default.
- W2079542864 cites W2089603681 @default.
- W2079542864 cites W2110803235 @default.
- W2079542864 cites W2110895340 @default.
- W2079542864 cites W2150079385 @default.
- W2079542864 cites W2161845595 @default.
- W2079542864 cites W2163865157 @default.
- W2079542864 cites W2166650033 @default.
- W2079542864 cites W2168079709 @default.
- W2079542864 cites W2187880154 @default.
- W2079542864 cites W2189324742 @default.
- W2079542864 cites W2272870230 @default.
- W2079542864 cites W2325036290 @default.
- W2079542864 cites W2418913756 @default.
- W2079542864 cites W2947147947 @default.
- W2079542864 cites W37591249 @default.
- W2079542864 doi "https://doi.org/10.1002/jor.21005" @default.
- W2079542864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19859898" @default.
- W2079542864 hasPublicationYear "2009" @default.
- W2079542864 type Work @default.
- W2079542864 sameAs 2079542864 @default.
- W2079542864 citedByCount "8" @default.
- W2079542864 countsByYear W20795428642012 @default.
- W2079542864 countsByYear W20795428642013 @default.
- W2079542864 countsByYear W20795428642015 @default.
- W2079542864 countsByYear W20795428642020 @default.
- W2079542864 countsByYear W20795428642021 @default.
- W2079542864 crossrefType "journal-article" @default.
- W2079542864 hasAuthorship W2079542864A5036708179 @default.
- W2079542864 hasAuthorship W2079542864A5068946700 @default.
- W2079542864 hasAuthorship W2079542864A5086444103 @default.
- W2079542864 hasConcept C105702510 @default.
- W2079542864 hasConcept C136229726 @default.
- W2079542864 hasConcept C142724271 @default.
- W2079542864 hasConcept C146562846 @default.
- W2079542864 hasConcept C185592680 @default.
- W2079542864 hasConcept C202751555 @default.
- W2079542864 hasConcept C2776872141 @default.
- W2079542864 hasConcept C2777236700 @default.
- W2079542864 hasConcept C2777674748 @default.
- W2079542864 hasConcept C2779079599 @default.
- W2079542864 hasConcept C2779330695 @default.
- W2079542864 hasConcept C2780165375 @default.
- W2079542864 hasConcept C41625074 @default.
- W2079542864 hasConcept C55493867 @default.
- W2079542864 hasConcept C71924100 @default.
- W2079542864 hasConcept C8337478 @default.
- W2079542864 hasConcept C89429830 @default.
- W2079542864 hasConceptScore W2079542864C105702510 @default.
- W2079542864 hasConceptScore W2079542864C136229726 @default.
- W2079542864 hasConceptScore W2079542864C142724271 @default.
- W2079542864 hasConceptScore W2079542864C146562846 @default.
- W2079542864 hasConceptScore W2079542864C185592680 @default.
- W2079542864 hasConceptScore W2079542864C202751555 @default.
- W2079542864 hasConceptScore W2079542864C2776872141 @default.
- W2079542864 hasConceptScore W2079542864C2777236700 @default.
- W2079542864 hasConceptScore W2079542864C2777674748 @default.
- W2079542864 hasConceptScore W2079542864C2779079599 @default.
- W2079542864 hasConceptScore W2079542864C2779330695 @default.
- W2079542864 hasConceptScore W2079542864C2780165375 @default.
- W2079542864 hasConceptScore W2079542864C41625074 @default.
- W2079542864 hasConceptScore W2079542864C55493867 @default.
- W2079542864 hasConceptScore W2079542864C71924100 @default.
- W2079542864 hasConceptScore W2079542864C8337478 @default.
- W2079542864 hasConceptScore W2079542864C89429830 @default.
- W2079542864 hasLocation W20795428641 @default.
- W2079542864 hasLocation W20795428642 @default.
- W2079542864 hasOpenAccess W2079542864 @default.
- W2079542864 hasPrimaryLocation W20795428641 @default.
- W2079542864 hasRelatedWork W1976650659 @default.
- W2079542864 hasRelatedWork W1996324943 @default.