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- W2079542914 abstract "A multidrug-resistant clone of human cancer KB cells was isolated by stepwise selection on exposure to increasing doses of vincristine. The final clone, VJ-300, obtained after ethylmethane sulfonate mutagenesis showed 400-fold higher resistance to vincristine than did KB cells. Cellular accumulation of vincristine in VJ-300 was decreased to less than one-tenth of that in KB. The cells were also cross-resistant to daunomycin, adriamycin, actinomycin D, colchicine and VP-16. During continuous culturing in the absence of any drug for several months, a different colchicine-resistant and multidrug-resistant clone, KB-C1, reverted almost completely to drug sensitivity, whereas drug resistance in VJ-300 was stably maintained. Amplification of the multidrug-resistance-1 (mdr-1) gene was more than 20-fold in KB-C1, but less than 2-fold in VJ-300. mdr-1 mRNA was, however, expressed in VJ-300 at a rate comparable to KB-C1. Acquisition of high multidrug resistance in VJ-300 might be correlated with both activated transcription of mdr-1 gene and amplification." @default.
- W2079542914 created "2016-06-24" @default.
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- W2079542914 date "1988-11-01" @default.
- W2079542914 modified "2023-10-16" @default.
- W2079542914 title "Vincristine-resistant Human Cancer KB Cell Line and Increased Expression of Multidrug-resistance Gene" @default.
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- W2079542914 doi "https://doi.org/10.1111/j.1349-7006.1988.tb01550.x" @default.
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