FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079543912> ?p ?o ?g. }

• W2079543912 endingPage "205" @default.
• W2079543912 startingPage "195" @default.
• W2079543912 abstract "The T lineage glycoprotein CD6 is generally considered to be a costimulator of T-cell activation. Here, we demonstrate that CD6 significantly reduces early and late T-cell responses upon superantigen stimulation or TCR triggering by Abs. Measuring calcium mobilization in single cells responding to superantigen, we found that human T cells expressing rat CD6 react significantly less well compared with T cells not expressing the exogenous receptor. When the cytoplasmic domain of rat CD6 was removed, calcium responses were recovered, indicating that the inhibitory properties of CD6 are attributable to its cytoplasmic domain. Calcium responses, and also late indicators of T-cell activation such as IL-2 release, were also diminished in TCR-activated Jurkat cells expressing human CD6, compared with CD6-deficient cells or cells expressing a cytoplasmic deletion mutant of human CD6. Similarly, calcium signals triggered by anti-CD3 were enhanced in human T lymphocytes following morpholino-mediated suppression of CD6 expression. Finally, the proliferation of T lymphocytes was increased when the CD6–CD166 interaction was blocked with anti-CD166 Abs, but inhibited when anti-CD6 Abs were used. Our data suggest that CD6 is a signaling attenuator whose expression alone, i.e. in the absence of ligand engagement, is sufficient to restrain signaling in T cells." @default.
• W2079543912 created "2016-06-24" @default.
• W2079543912 creator A5004705739 @default.
• W2079543912 creator A5026119359 @default.
• W2079543912 creator A5039265804 @default.
• W2079543912 creator A5052537206 @default.
• W2079543912 creator A5064309344 @default.
• W2079543912 creator A5064851147 @default.
• W2079543912 creator A5067601115 @default.
• W2079543912 creator A5068325938 @default.
• W2079543912 creator A5069732096 @default.
• W2079543912 creator A5084882474 @default.
• W2079543912 creator A5086910906 @default.
• W2079543912 creator A5089039225 @default.
• W2079543912 creator A5089516153 @default.
• W2079543912 creator A5090941731 @default.
• W2079543912 creator A5091864908 @default.
• W2079543912 date "2011-11-28" @default.
• W2079543912 modified "2023-10-17" @default.
• W2079543912 title "CD6 attenuates early and late signaling events, setting thresholds for T-cell activation" @default.
• W2079543912 cites W1489752262 @default.
• W2079543912 cites W1508584129 @default.
• W2079543912 cites W1522774123 @default.
• W2079543912 cites W1562116524 @default.
• W2079543912 cites W1594159197 @default.
• W2079543912 cites W1597652464 @default.
• W2079543912 cites W1631781682 @default.
• W2079543912 cites W187515065 @default.
• W2079543912 cites W1908145345 @default.
• W2079543912 cites W1930525379 @default.
• W2079543912 cites W1964013439 @default.
• W2079543912 cites W1967506712 @default.
• W2079543912 cites W1977137008 @default.
• W2079543912 cites W1999809860 @default.
• W2079543912 cites W2004740433 @default.
• W2079543912 cites W2005874078 @default.
• W2079543912 cites W2022532491 @default.
• W2079543912 cites W2035469701 @default.
• W2079543912 cites W2042342193 @default.
• W2079543912 cites W2047207866 @default.
• W2079543912 cites W2050702954 @default.
• W2079543912 cites W2052249831 @default.
• W2079543912 cites W2065471902 @default.
• W2079543912 cites W2065876190 @default.
• W2079543912 cites W2066668926 @default.
• W2079543912 cites W2070011436 @default.
• W2079543912 cites W2070827084 @default.
• W2079543912 cites W2088953433 @default.
• W2079543912 cites W2093238184 @default.
• W2079543912 cites W2098882468 @default.
• W2079543912 cites W2101433730 @default.
• W2079543912 cites W2121653179 @default.
• W2079543912 cites W2125246887 @default.
• W2079543912 cites W2129903115 @default.
• W2079543912 cites W2130779526 @default.
• W2079543912 cites W2141826840 @default.
• W2079543912 cites W2142685018 @default.
• W2079543912 cites W2143600483 @default.
• W2079543912 cites W2147971828 @default.
• W2079543912 cites W2156587144 @default.
• W2079543912 cites W2157725183 @default.
• W2079543912 cites W4239139991 @default.
• W2079543912 cites W4313314629 @default.
• W2079543912 doi "https://doi.org/10.1002/eji.201040528" @default.
• W2079543912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3298641" @default.
• W2079543912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21956609" @default.
• W2079543912 hasPublicationYear "2011" @default.
• W2079543912 type Work @default.
• W2079543912 sameAs 2079543912 @default.
• W2079543912 citedByCount "56" @default.
• W2079543912 countsByYear W20795439122013 @default.
• W2079543912 countsByYear W20795439122014 @default.
• W2079543912 countsByYear W20795439122015 @default.
• W2079543912 countsByYear W20795439122016 @default.
• W2079543912 countsByYear W20795439122017 @default.
• W2079543912 countsByYear W20795439122018 @default.
• W2079543912 countsByYear W20795439122019 @default.
• W2079543912 countsByYear W20795439122020 @default.
• W2079543912 countsByYear W20795439122021 @default.
• W2079543912 countsByYear W20795439122022 @default.
• W2079543912 countsByYear W20795439122023 @default.
• W2079543912 crossrefType "journal-article" @default.
• W2079543912 hasAuthorship W2079543912A5004705739 @default.
• W2079543912 hasAuthorship W2079543912A5026119359 @default.
• W2079543912 hasAuthorship W2079543912A5039265804 @default.
• W2079543912 hasAuthorship W2079543912A5052537206 @default.
• W2079543912 hasAuthorship W2079543912A5064309344 @default.
• W2079543912 hasAuthorship W2079543912A5064851147 @default.
• W2079543912 hasAuthorship W2079543912A5067601115 @default.
• W2079543912 hasAuthorship W2079543912A5068325938 @default.
• W2079543912 hasAuthorship W2079543912A5069732096 @default.
• W2079543912 hasAuthorship W2079543912A5084882474 @default.
• W2079543912 hasAuthorship W2079543912A5086910906 @default.
• W2079543912 hasAuthorship W2079543912A5089039225 @default.
• W2079543912 hasAuthorship W2079543912A5089516153 @default.
• W2079543912 hasAuthorship W2079543912A5090941731 @default.
• W2079543912 hasAuthorship W2079543912A5091864908 @default.
• W2079543912 hasBestOaLocation W20795439121 @default.

• next