Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079550884> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W2079550884 endingPage "120" @default.
- W2079550884 startingPage "120" @default.
- W2079550884 abstract "Fluoro-2-deoxy-d-glucose<i>-</i>positron emission tomography (FDG-PET) is utilized in more than 90% of cancers in staging, re-staging, assessing therapy response and during the follow-up. However, not all tumors show significant increase of metabolic activity on FDG-PET imaging. This is particularly true for prostate cancer, neuroendocrine tumors and hepatic tumors. In this review we have considered those already used for clinical applications such as 11C- and 18F-Choline, 11C-Methionine and 18F-FET, 18F-DOPA, 68Ga-DOTA-somatostatine analogues, 11C-Acetate and 18F-FLT.<b> </b> Choline presents a high affinity for malignant prostate tissue, even if low grade. Choline can be labeled with either 11C or 18F, the former being the preference due to lower urinary excretion and patients exposure. The latter is more useful for possible distribution to centers lacking in on-site cyclotron. Methionine is needed for protein synthesis and tumor cells require an external supply of methionine. These tracers have primarily been used for imaging of CNS neoplasms. The most appropriate indication is when conventional imaging procedures do not distinguish between edema, fibrosis or necrosis and disease relapse. In addition, the uptake of 11C-Methionine is proportional to the tumor grade and, therefore, the maximum small unilamellar vesicles (SUV) inside the brain mass before therapy is somehow considered a prognostic value. Neuroendocrine tumors (carcinoids, pheocromocytoma, neuroblastoma, medullary thyroid cancer, microcytoma, carotid glomus tumors, and melanoma) demonstrate an increased activity of L-DOPA decarboxylase, and hence they show a high uptake of 18FDOPA. For the study of NETs, 68Ga-DOTA-TOC/DOTA-NOC has been introduced as PET tracer. This compound for PET imaging has a high affinity for sst2 and sst5 and has been used in the detection of NETs in preliminary studies; 68Ga-DOTA-NOC PET is useful before metabolic radiotherapy in order to evaluate the biodistribution of the therapeutic compound; 18F-FLT is a specific marker of cell proliferation and the most important field of application of FLT is lung cancer. Other tracers are used in PET utilized as markers of hypoxia inside big neoplastic masses include 18F-MISO, 64Cu-ATSM, 18F-EF5, which highlight the presence of hypoxic areas are useful for patients that must be treated with radiotherapy." @default.
- W2079550884 created "2016-06-24" @default.
- W2079550884 creator A5058812950 @default.
- W2079550884 creator A5059462029 @default.
- W2079550884 creator A5060396380 @default.
- W2079550884 creator A5063023121 @default.
- W2079550884 creator A5088003622 @default.
- W2079550884 date "2010-01-01" @default.
- W2079550884 modified "2023-10-18" @default.
- W2079550884 title "Non-FDG PET in the practice of oncology" @default.
- W2079550884 cites W2135658869 @default.
- W2079550884 cites W2344395172 @default.
- W2079550884 doi "https://doi.org/10.4103/0019-509x.62998" @default.
- W2079550884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20448372" @default.
- W2079550884 hasPublicationYear "2010" @default.
- W2079550884 type Work @default.
- W2079550884 sameAs 2079550884 @default.
- W2079550884 citedByCount "44" @default.
- W2079550884 countsByYear W20795508842012 @default.
- W2079550884 countsByYear W20795508842013 @default.
- W2079550884 countsByYear W20795508842014 @default.
- W2079550884 countsByYear W20795508842015 @default.
- W2079550884 countsByYear W20795508842016 @default.
- W2079550884 countsByYear W20795508842018 @default.
- W2079550884 countsByYear W20795508842019 @default.
- W2079550884 countsByYear W20795508842020 @default.
- W2079550884 countsByYear W20795508842021 @default.
- W2079550884 countsByYear W20795508842022 @default.
- W2079550884 crossrefType "journal-article" @default.
- W2079550884 hasAuthorship W2079550884A5058812950 @default.
- W2079550884 hasAuthorship W2079550884A5059462029 @default.
- W2079550884 hasAuthorship W2079550884A5060396380 @default.
- W2079550884 hasAuthorship W2079550884A5063023121 @default.
- W2079550884 hasAuthorship W2079550884A5088003622 @default.
- W2079550884 hasConcept C121608353 @default.
- W2079550884 hasConcept C126322002 @default.
- W2079550884 hasConcept C185592680 @default.
- W2079550884 hasConcept C2775842073 @default.
- W2079550884 hasConcept C2777658100 @default.
- W2079550884 hasConcept C2779066768 @default.
- W2079550884 hasConcept C2780192828 @default.
- W2079550884 hasConcept C2780912031 @default.
- W2079550884 hasConcept C2989005 @default.
- W2079550884 hasConcept C502942594 @default.
- W2079550884 hasConcept C515207424 @default.
- W2079550884 hasConcept C55493867 @default.
- W2079550884 hasConcept C71924100 @default.
- W2079550884 hasConceptScore W2079550884C121608353 @default.
- W2079550884 hasConceptScore W2079550884C126322002 @default.
- W2079550884 hasConceptScore W2079550884C185592680 @default.
- W2079550884 hasConceptScore W2079550884C2775842073 @default.
- W2079550884 hasConceptScore W2079550884C2777658100 @default.
- W2079550884 hasConceptScore W2079550884C2779066768 @default.
- W2079550884 hasConceptScore W2079550884C2780192828 @default.
- W2079550884 hasConceptScore W2079550884C2780912031 @default.
- W2079550884 hasConceptScore W2079550884C2989005 @default.
- W2079550884 hasConceptScore W2079550884C502942594 @default.
- W2079550884 hasConceptScore W2079550884C515207424 @default.
- W2079550884 hasConceptScore W2079550884C55493867 @default.
- W2079550884 hasConceptScore W2079550884C71924100 @default.
- W2079550884 hasIssue "2" @default.
- W2079550884 hasLocation W20795508841 @default.
- W2079550884 hasLocation W20795508842 @default.
- W2079550884 hasOpenAccess W2079550884 @default.
- W2079550884 hasPrimaryLocation W20795508841 @default.
- W2079550884 hasRelatedWork W2008510454 @default.
- W2079550884 hasRelatedWork W2021968456 @default.
- W2079550884 hasRelatedWork W2068861579 @default.
- W2079550884 hasRelatedWork W2323318725 @default.
- W2079550884 hasRelatedWork W2408887968 @default.
- W2079550884 hasRelatedWork W2412245334 @default.
- W2079550884 hasRelatedWork W2439790458 @default.
- W2079550884 hasRelatedWork W2981372661 @default.
- W2079550884 hasRelatedWork W4293020281 @default.
- W2079550884 hasRelatedWork W4290320799 @default.
- W2079550884 hasVolume "47" @default.
- W2079550884 isParatext "false" @default.
- W2079550884 isRetracted "false" @default.
- W2079550884 magId "2079550884" @default.
- W2079550884 workType "article" @default.