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- W2079551344 abstract "alpha-Aryl ketones react with vinamidinium hexafluorophosphate salts to give access to the corresponding 3-arylpyridines. The annulation reactions proceed in good to excellent yields with vinamidinium salts containing electron-withdrawing groups at the beta-position (R(2)). The reaction was applied to the preparation of the COX-2 specific inhibitor 5-chloro-3-(4-methylsulfonyl)phenyl-2-(2-methyl-5-pyridinyl)pyridine (1), as well as a series of analogues." @default.
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- W2079551344 date "2000-06-30" @default.
- W2079551344 modified "2023-10-17" @default.
- W2079551344 title "Annulation of Ketones with Vinamidinium Hexafluorophosphate Salts: An Efficient Preparation of Trisubstituted Pyridines" @default.
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- W2079551344 doi "https://doi.org/10.1021/ol006097b" @default.
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