Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079551770> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079551770 endingPage "128" @default.
- W2079551770 startingPage "119" @default.
- W2079551770 abstract "The translation machineries of different host cells may exhibit varying requirements for a specific structure of cis-acting control elements in the viral RNA templates. Thus, the appropriately spaced oligopyrimidine/AUG tandem (OAT), a conserved control element in the 5' noncoding region of the picornavirus genomes, is dispensable for the growth of Theiler's murine encephalomyelitis virus (TMEV) in BHK-21 cells, but is essential for the neurovirulence of this virus. Also, the replacement of the cryptic (non-initiator) AUG moiety of the wild-type poliovirus OAT by the initiator AUG affects the viral reproduction in cultured cells only slightly, whereas neurovirulence of the relevant mutants is dramatically suppressed. These observations allow us to propose a rational way to construct novel attenuated viral strains by elimination or severe modification of host-specific regulatory regions in their genomes. The relevant genetic rearrangements may be so extensive that the probability of reversion to the virulent phenotype should be negligible. The feasibility of engineering of highly attenuated and genetically stable TMEV and poliovirus variants is illustrated." @default.
- W2079551770 created "2016-06-24" @default.
- W2079551770 creator A5051395220 @default.
- W2079551770 creator A5071411200 @default.
- W2079551770 creator A5083094159 @default.
- W2079551770 date "1996-01-01" @default.
- W2079551770 modified "2023-09-28" @default.
- W2079551770 title "Modification of translational control elements as a new approach to design of attenuated picornavirus strains" @default.
- W2079551770 cites W1530616637 @default.
- W2079551770 cites W1571685587 @default.
- W2079551770 cites W1807212217 @default.
- W2079551770 cites W1969723726 @default.
- W2079551770 cites W1980651825 @default.
- W2079551770 cites W1984220174 @default.
- W2079551770 cites W1991536902 @default.
- W2079551770 cites W2012587168 @default.
- W2079551770 cites W2013855627 @default.
- W2079551770 cites W2023403791 @default.
- W2079551770 cites W2031160282 @default.
- W2079551770 cites W2033294120 @default.
- W2079551770 cites W2048731469 @default.
- W2079551770 cites W2050502218 @default.
- W2079551770 cites W2058423707 @default.
- W2079551770 cites W2067146710 @default.
- W2079551770 cites W2072115742 @default.
- W2079551770 cites W2072397017 @default.
- W2079551770 cites W2087177299 @default.
- W2079551770 cites W210039449 @default.
- W2079551770 cites W2103410475 @default.
- W2079551770 cites W2131085431 @default.
- W2079551770 doi "https://doi.org/10.1016/0168-1656(95)00088-7" @default.
- W2079551770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8717395" @default.
- W2079551770 hasPublicationYear "1996" @default.
- W2079551770 type Work @default.
- W2079551770 sameAs 2079551770 @default.
- W2079551770 citedByCount "26" @default.
- W2079551770 countsByYear W20795517702012 @default.
- W2079551770 countsByYear W20795517702013 @default.
- W2079551770 countsByYear W20795517702014 @default.
- W2079551770 countsByYear W20795517702015 @default.
- W2079551770 countsByYear W20795517702018 @default.
- W2079551770 countsByYear W20795517702020 @default.
- W2079551770 crossrefType "journal-article" @default.
- W2079551770 hasAuthorship W2079551770A5051395220 @default.
- W2079551770 hasAuthorship W2079551770A5071411200 @default.
- W2079551770 hasAuthorship W2079551770A5083094159 @default.
- W2079551770 hasConcept C104317684 @default.
- W2079551770 hasConcept C105580179 @default.
- W2079551770 hasConcept C141231307 @default.
- W2079551770 hasConcept C143065580 @default.
- W2079551770 hasConcept C149364088 @default.
- W2079551770 hasConcept C159047783 @default.
- W2079551770 hasConcept C2522874641 @default.
- W2079551770 hasConcept C2778009244 @default.
- W2079551770 hasConcept C2779631682 @default.
- W2079551770 hasConcept C54355233 @default.
- W2079551770 hasConcept C60987743 @default.
- W2079551770 hasConcept C67705224 @default.
- W2079551770 hasConcept C86803240 @default.
- W2079551770 hasConceptScore W2079551770C104317684 @default.
- W2079551770 hasConceptScore W2079551770C105580179 @default.
- W2079551770 hasConceptScore W2079551770C141231307 @default.
- W2079551770 hasConceptScore W2079551770C143065580 @default.
- W2079551770 hasConceptScore W2079551770C149364088 @default.
- W2079551770 hasConceptScore W2079551770C159047783 @default.
- W2079551770 hasConceptScore W2079551770C2522874641 @default.
- W2079551770 hasConceptScore W2079551770C2778009244 @default.
- W2079551770 hasConceptScore W2079551770C2779631682 @default.
- W2079551770 hasConceptScore W2079551770C54355233 @default.
- W2079551770 hasConceptScore W2079551770C60987743 @default.
- W2079551770 hasConceptScore W2079551770C67705224 @default.
- W2079551770 hasConceptScore W2079551770C86803240 @default.
- W2079551770 hasIssue "1-3" @default.
- W2079551770 hasLocation W20795517701 @default.
- W2079551770 hasLocation W20795517702 @default.
- W2079551770 hasOpenAccess W2079551770 @default.
- W2079551770 hasPrimaryLocation W20795517701 @default.
- W2079551770 hasRelatedWork W1542085368 @default.
- W2079551770 hasRelatedWork W1587390811 @default.
- W2079551770 hasRelatedWork W1984508034 @default.
- W2079551770 hasRelatedWork W1986137505 @default.
- W2079551770 hasRelatedWork W2001445920 @default.
- W2079551770 hasRelatedWork W2012539582 @default.
- W2079551770 hasRelatedWork W2086778880 @default.
- W2079551770 hasRelatedWork W2215267072 @default.
- W2079551770 hasRelatedWork W3045355607 @default.
- W2079551770 hasRelatedWork W3141311855 @default.
- W2079551770 hasVolume "44" @default.
- W2079551770 isParatext "false" @default.
- W2079551770 isRetracted "false" @default.
- W2079551770 magId "2079551770" @default.
- W2079551770 workType "article" @default.