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- W2079551885 endingPage "e38905" @default.
- W2079551885 startingPage "e38905" @default.
- W2079551885 abstract "HIV-1 nucleocapsid protein (NC) is involved in the rearrangement of nucleic acids occurring in key steps of reverse transcription. The protein, through its two zinc fingers, interacts preferentially with unpaired guanines in single-stranded sequences. In mini-cTAR stem-loop, which corresponds to the top half of the cDNA copy of the transactivation response element of the HIV-1 genome, NC was found to exhibit a clear preference for the TGG sequence at the bottom of mini-cTAR stem. To further understand how this site was selected among several potential binding sites containing unpaired guanines, we probed the intrinsic dynamics of mini-cTAR using 13C relaxation measurements. Results of spin relaxation time measurements have been analyzed using the model-free formalism and completed by dispersion relaxation measurements. Our data indicate that the preferentially recognized guanine in the lower part of the stem is exempt of conformational exchange and highly mobile. In contrast, the unrecognized unpaired guanines of mini-cTAR are involved in conformational exchange, probably related to transient base-pairs. These findings support the notion that NC preferentially recognizes unpaired guanines exhibiting a high degree of mobility. The ability of NC to discriminate between close sequences through their dynamic properties contributes to understanding how NC recognizes specific sites within the HIV genome." @default.
- W2079551885 created "2016-06-24" @default.
- W2079551885 creator A5013024180 @default.
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- W2079551885 date "2012-06-20" @default.
- W2079551885 modified "2023-09-26" @default.
- W2079551885 title "Intrinsic Nucleic Acid Dynamics Modulates HIV-1 Nucleocapsid Protein Binding to Its Targets" @default.
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- W2079551885 doi "https://doi.org/10.1371/journal.pone.0038905" @default.
- W2079551885 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3380039" @default.
- W2079551885 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22745685" @default.
- W2079551885 hasPublicationYear "2012" @default.
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