FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079552893> ?p ?o ?g. }

• W2079552893 endingPage "263" @default.
• W2079552893 startingPage "252" @default.
• W2079552893 abstract "Amiodarone (AD) is an iodinated benzofuran derivative, especially known for its antiarrhythmic properties. It exerts serious side-effects even in patients receiving low doses. AD is well-known to induce apoptosis of type II alveolar epithelial cells (AECII), a mechanism that has been suggested to play an important role in AD-induced lung fibrosis. The precise molecular mechanisms underlying this disease are, however, still unclear. Because of its amphiphilic nature, AD becomes enriched in the lysosomal compartments, affecting the general functions of these organelles. Hence, in this study, we aimed to assess the role of autophagy, a lysosome-dependent homeostasis mechanism, in driving AECII apoptosis in response to AD. In vitro, AD-treated MLE12 and primary AECII cells showed increased proSP-C and LC3B positive vacuolar structures and underwent LC3B-dependent apoptosis. In addition, AD-induced autophagosome-lysosome fusion and increased autophagy flux were observed. In vivo, in C57BL/6 mice, LC3B was localised at the limiting membrane of lamellar bodies, which were closely connected to the autophagosomal structures in AECIIs. Our data suggest that AD causes activation of macroautophagy in AECIIs and extensive autophagy-dependent apoptosis of alveolar epithelial cells. Targeting the autophagy pathway may therefore represent an attractive treatment modality in AD-induced lung fibrosis." @default.
• W2079552893 created "2016-06-24" @default.
• W2079552893 creator A5005230196 @default.
• W2079552893 creator A5016511599 @default.
• W2079552893 creator A5024146682 @default.
• W2079552893 creator A5027694995 @default.
• W2079552893 creator A5031943939 @default.
• W2079552893 creator A5040299849 @default.
• W2079552893 creator A5043026704 @default.
• W2079552893 creator A5044036919 @default.
• W2079552893 creator A5047185790 @default.
• W2079552893 creator A5066849323 @default.
• W2079552893 creator A5079656524 @default.
• W2079552893 creator A5088745294 @default.
• W2079552893 creator A5089182357 @default.
• W2079552893 date "2015-06-03" @default.
• W2079552893 modified "2023-10-16" @default.
• W2079552893 title "Regulation of macroautophagy in amiodarone-induced pulmonary fibrosis" @default.
• W2079552893 cites W1523693806 @default.
• W2079552893 cites W1529904845 @default.
• W2079552893 cites W1899861597 @default.
• W2079552893 cites W1964763909 @default.
• W2079552893 cites W1971763588 @default.
• W2079552893 cites W1987769185 @default.
• W2079552893 cites W1990421784 @default.
• W2079552893 cites W1991372364 @default.
• W2079552893 cites W1994823455 @default.
• W2079552893 cites W1998192361 @default.
• W2079552893 cites W2003887174 @default.
• W2079552893 cites W2016243515 @default.
• W2079552893 cites W2017334419 @default.
• W2079552893 cites W2022824022 @default.
• W2079552893 cites W2024919277 @default.
• W2079552893 cites W2025362788 @default.
• W2079552893 cites W2026834042 @default.
• W2079552893 cites W2033990067 @default.
• W2079552893 cites W2049991946 @default.
• W2079552893 cites W2051301953 @default.
• W2079552893 cites W2056636564 @default.
• W2079552893 cites W2059922024 @default.
• W2079552893 cites W2063345075 @default.
• W2079552893 cites W2066409437 @default.
• W2079552893 cites W2067311459 @default.
• W2079552893 cites W2080278927 @default.
• W2079552893 cites W2084996545 @default.
• W2079552893 cites W2087066083 @default.
• W2079552893 cites W2087205488 @default.
• W2079552893 cites W2101965284 @default.
• W2079552893 cites W2103391985 @default.
• W2079552893 cites W2105058961 @default.
• W2079552893 cites W2108086395 @default.
• W2079552893 cites W2121394112 @default.
• W2079552893 cites W2127805957 @default.
• W2079552893 cites W2130498948 @default.
• W2079552893 cites W2133435868 @default.
• W2079552893 cites W2139458682 @default.
• W2079552893 cites W2141887125 @default.
• W2079552893 cites W2141976152 @default.
• W2079552893 cites W2145472547 @default.
• W2079552893 cites W2157200088 @default.
• W2079552893 cites W2161082864 @default.
• W2079552893 cites W2164778558 @default.
• W2079552893 cites W2166389250 @default.
• W2079552893 cites W2188452357 @default.
• W2079552893 doi "https://doi.org/10.1002/cjp2.20" @default.
• W2079552893 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4939895" @default.
• W2079552893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27499909" @default.
• W2079552893 hasPublicationYear "2015" @default.
• W2079552893 type Work @default.
• W2079552893 sameAs 2079552893 @default.
• W2079552893 citedByCount "26" @default.
• W2079552893 countsByYear W20795528932016 @default.
• W2079552893 countsByYear W20795528932017 @default.
• W2079552893 countsByYear W20795528932018 @default.
• W2079552893 countsByYear W20795528932019 @default.
• W2079552893 countsByYear W20795528932020 @default.
• W2079552893 countsByYear W20795528932021 @default.
• W2079552893 countsByYear W20795528932022 @default.
• W2079552893 countsByYear W20795528932023 @default.
• W2079552893 crossrefType "journal-article" @default.
• W2079552893 hasAuthorship W2079552893A5005230196 @default.
• W2079552893 hasAuthorship W2079552893A5016511599 @default.
• W2079552893 hasAuthorship W2079552893A5024146682 @default.
• W2079552893 hasAuthorship W2079552893A5027694995 @default.
• W2079552893 hasAuthorship W2079552893A5031943939 @default.
• W2079552893 hasAuthorship W2079552893A5040299849 @default.
• W2079552893 hasAuthorship W2079552893A5043026704 @default.
• W2079552893 hasAuthorship W2079552893A5044036919 @default.
• W2079552893 hasAuthorship W2079552893A5047185790 @default.
• W2079552893 hasAuthorship W2079552893A5066849323 @default.
• W2079552893 hasAuthorship W2079552893A5079656524 @default.
• W2079552893 hasAuthorship W2079552893A5088745294 @default.
• W2079552893 hasAuthorship W2079552893A5089182357 @default.
• W2079552893 hasBestOaLocation W20795528931 @default.
• W2079552893 hasConcept C126322002 @default.
• W2079552893 hasConcept C142724271 @default.
• W2079552893 hasConcept C145156650 @default.
• W2079552893 hasConcept C168296220 @default.

• next