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- W2079555838 abstract "Skeletal muscle MRI T2-mapping is known to detect oedematous/inflammatory/necrotic sites, which are all characterized by elevated global (monoexponential) water T2-values. Although revealing disease activity, the lack of specificity of this measurement precludes its application for the characterization of the specific pathophysiological mechanisms underlying disease progression. The T2 relaxation of 1 H NMR signals in skeletal muscle tissue has been long known to be multiexponential. This is currently agreed to reveal anatomical compartmentation of myowater. The spectroscopic CPMG sequence allows the acquisition of T2-relaxation curves with echo-time sampling and SNR significantly higher than MRI methods and offers the possibility for robust multiexponential analysis. CPMG data ( Nb of echoes =1000, inter-echo-spacing =1ms) were acquired from within the soleus of 8 healthy volunteers and 3 patients with muscular disorders. T2-spectra were extracted for each set of data using a regularized inversion method. T2-spectra observed in healthy volunteers systematically presented two T2-peaks centred at T2=32 and 132ms, with relative fractions of 93% and 7%, respectively. In patients, the observed T2-spectra were drastically altered; the peaks are shifted and closer to each other and in some cases coalescent. The results demonstrated the high sensitivity of T2-spectra to disease activity. In healthy subjects, prior knowledge about mean transmembrane water exchange rates allows a compartmental-exchange-analysis of the T2-spectra in order to characterize the different tissue compartments by their T2 and relative fraction. Although more exhaustive investigation is necessary to quantitatively interpret the alterations of T2-spectra in diseased tissue, such information shall give specificity to MRI T2 measurements by revealing physiological mechanisms underlying observed monoexponential T2 alterations." @default.
- W2079555838 created "2016-06-24" @default.
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- W2079555838 date "2014-10-01" @default.
- W2079555838 modified "2023-09-25" @default.
- W2079555838 title "G.P.122" @default.
- W2079555838 doi "https://doi.org/10.1016/j.nmd.2014.06.152" @default.
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