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• W2079556486 abstract "Abstract Aim: Genome‐wide association studies have described variants within the interleukin‐23 receptor ( IL23R ) locus to be associated with Crohn’s disease (CD) and ulcerative colitis (UC). We investigated the association of rs11209026 (p.Arg381Gln) and rs7517847 (c.799‐3588T>G) into German paediatric inflammatory bowel disease (IBD) patients and analysed IL23R transcriptional activity in colonic tissues. Methods: The rs11209026 and rs7517847 nucleotide substitutions were determined in 353 German children with IBD (221 CD, 132 UC) and 253 controls using pre‐designed TaqMan ® SNP genotyping assays. In selected IBD patients and controls, IL23R mRNA expression was measured using real‐time PCR. Results: The prevalence of the rs11209026 A allele was lower in CD patients, but not in UC patients, when compared with controls (1.8% vs 7.1%, p < 0.01). The rs7517847 variant, in contrast, was associated neither with CD nor with UC. IL23R expression was variable in IBD patients compared with controls without significant overexpression or downregulation. Conclusion: Our study provides additional support for the strong protection of the rs11209026 (p.Arg381Gln) variant against paediatric CD. IL23R was expressed in both CD and UC with a great variability. However, expression levels showed no significant association with the disease." @default.
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• W2079556486 date "2010-03-29" @default.
• W2079556486 modified "2023-10-18" @default.
• W2079556486 title "Association of the <i>interleukin-23 receptor</i> gene variant rs11209026 with Crohn’s disease in German children" @default.
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• W2079556486 doi "https://doi.org/10.1111/j.1651-2227.2009.01680.x" @default.
• W2079556486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20192940" @default.
• W2079556486 hasPublicationYear "2010" @default.
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