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• W2079557259 abstract "A key step in the regulation of transcription involves interactions between promoter-selective factors and various components of the transcriptional apparatus. Here we report the requirements for transcriptional activation directed by NTF-1, a developmentally regulated transcription factor in Drosophila. Reconstituted transcription with fractionated Drosophila basal factors reveals that activation by NTF-1 requires factors present in the endogenous TFIID fraction that are distinct from the purified TATA-binding protein (TBP). Glycerol gradient sedimentation and immunoprecipitation analyses indicate that TFIID is a multiprotein complex containing TBP and at least six tightly bound TBP-associated factors (TAFs). Preparations of TBP lacking TAFs after fractionation with denaturants no longer support activation by NTF-1 but retain basal level activity. Addition of immunopurified and renatured TAFs to free TBP restores the ability of NTF-1 to activate transcription without influencing basal transcription. These results suggest that one or more of the TAF polypeptides confer coactivator function." @default.
• W2079557259 created "2016-06-24" @default.
• W2079557259 creator A5020711185 @default.
• W2079557259 creator A5079033247 @default.
• W2079557259 creator A5082330841 @default.
• W2079557259 date "1991-08-01" @default.
• W2079557259 modified "2023-10-17" @default.
• W2079557259 title "Isolation of coactivators associated with the TATA-binding protein that mediate transcriptional activation" @default.
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• W2079557259 doi "https://doi.org/10.1016/0092-8674(81)90019-2" @default.
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