FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079557671> ?p ?o ?g. }

• W2079557671 endingPage "112" @default.
• W2079557671 startingPage "101" @default.
• W2079557671 abstract "A peroxidase from yeast that reduces H2O2 with the use of electrons provided by thioredoxin (Trx) together with homologs from a wide variety of species constitute the peroxiredoxin (Prx) family of proteins. Twelve mammalian Prx members have been previously identified in association with various cellular functions apparently unrelated to peroxidase activity. These mammalian proteins have now been divided into three distinct types, Prx I, II, and III, on the basis of their deduced amino acid sequences and immunological reactivity. With the use of recombinant proteins, Prx I, II, and III have now been shown to possess peroxidase activity and to rely on Trx as a source of reducing equivalents. None of the three proteins exhibited peroxidase activity in the presence of glutaredoxin. All three enzymes showed similar kinetic properties: the Vmax was 6-13 micromol/min per mg at 37 degrees C, the Km for Trx was 3-6 microM, and the Km for H2O2 was < 20 microM. Immunoblot analysis of various rat tissues and cultured cells indicated that most cell types contain the three Prx isoforms, the sum of which amounts to approximately 1-10 microg per milligram of soluble protein. Prx I and II are cytosolic proteins, whereas Prx IlI is localized in mitochondria. These results suggest that, together with glutathione peroxidase and catalase, Prx enzymes likely play an important role in eliminating peroxides generated during metabolism as well as during stimulation of cell surface receptors." @default.
• W2079557671 created "2016-06-24" @default.
• W2079557671 creator A5020693621 @default.
• W2079557671 creator A5020834497 @default.
• W2079557671 creator A5060926806 @default.
• W2079557671 creator A5062049997 @default.
• W2079557671 date "1999-09-01" @default.
• W2079557671 modified "2023-10-18" @default.
• W2079557671 title "Characterization of three isoforms of mammalian peroxiredoxin that reduce peroxides in the presence of thioredoxin" @default.
• W2079557671 cites W1270671049 @default.
• W2079557671 cites W1483721839 @default.
• W2079557671 cites W1484105951 @default.
• W2079557671 cites W1528630840 @default.
• W2079557671 cites W1546592314 @default.
• W2079557671 cites W1568529372 @default.
• W2079557671 cites W1588367297 @default.
• W2079557671 cites W1589043152 @default.
• W2079557671 cites W1595716614 @default.
• W2079557671 cites W1638074023 @default.
• W2079557671 cites W1810600521 @default.
• W2079557671 cites W1868897194 @default.
• W2079557671 cites W196390227 @default.
• W2079557671 cites W1970405699 @default.
• W2079557671 cites W1978354385 @default.
• W2079557671 cites W1990348497 @default.
• W2079557671 cites W1992533564 @default.
• W2079557671 cites W1993055408 @default.
• W2079557671 cites W2000266931 @default.
• W2079557671 cites W2006723796 @default.
• W2079557671 cites W2008577285 @default.
• W2079557671 cites W2017265125 @default.
• W2079557671 cites W2020400942 @default.
• W2079557671 cites W2023247989 @default.
• W2079557671 cites W2025332686 @default.
• W2079557671 cites W2037313086 @default.
• W2079557671 cites W2044149640 @default.
• W2079557671 cites W2045787232 @default.
• W2079557671 cites W2048569323 @default.
• W2079557671 cites W2072569792 @default.
• W2079557671 cites W2073690504 @default.
• W2079557671 cites W2081748849 @default.
• W2079557671 cites W2088575436 @default.
• W2079557671 cites W2092463196 @default.
• W2079557671 cites W2096609115 @default.
• W2079557671 cites W2109662937 @default.
• W2079557671 cites W2110182057 @default.
• W2079557671 cites W2149870206 @default.
• W2079557671 cites W2179490209 @default.
• W2079557671 cites W2340885834 @default.
• W2079557671 doi "https://doi.org/10.1016/s0168-8227(99)00037-6" @default.
• W2079557671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10588361" @default.
• W2079557671 hasPublicationYear "1999" @default.
• W2079557671 type Work @default.
• W2079557671 sameAs 2079557671 @default.
• W2079557671 citedByCount "360" @default.
• W2079557671 countsByYear W20795576712012 @default.
• W2079557671 countsByYear W20795576712013 @default.
• W2079557671 countsByYear W20795576712014 @default.
• W2079557671 countsByYear W20795576712015 @default.
• W2079557671 countsByYear W20795576712016 @default.
• W2079557671 countsByYear W20795576712017 @default.
• W2079557671 countsByYear W20795576712018 @default.
• W2079557671 countsByYear W20795576712019 @default.
• W2079557671 countsByYear W20795576712020 @default.
• W2079557671 countsByYear W20795576712021 @default.
• W2079557671 countsByYear W20795576712022 @default.
• W2079557671 countsByYear W20795576712023 @default.
• W2079557671 crossrefType "journal-article" @default.
• W2079557671 hasAuthorship W2079557671A5020693621 @default.
• W2079557671 hasAuthorship W2079557671A5020834497 @default.
• W2079557671 hasAuthorship W2079557671A5060926806 @default.
• W2079557671 hasAuthorship W2079557671A5062049997 @default.
• W2079557671 hasConcept C104317684 @default.
• W2079557671 hasConcept C119795356 @default.
• W2079557671 hasConcept C125619963 @default.
• W2079557671 hasConcept C153911025 @default.
• W2079557671 hasConcept C155064970 @default.
• W2079557671 hasConcept C162008176 @default.
• W2079557671 hasConcept C181199279 @default.
• W2079557671 hasConcept C203663253 @default.
• W2079557671 hasConcept C2778760513 @default.
• W2079557671 hasConcept C2778979269 @default.
• W2079557671 hasConcept C2780416994 @default.
• W2079557671 hasConcept C3623737 @default.
• W2079557671 hasConcept C40767141 @default.
• W2079557671 hasConcept C53345823 @default.
• W2079557671 hasConcept C55493867 @default.
• W2079557671 hasConcept C86803240 @default.
• W2079557671 hasConcept C98539663 @default.
• W2079557671 hasConceptScore W2079557671C104317684 @default.
• W2079557671 hasConceptScore W2079557671C119795356 @default.
• W2079557671 hasConceptScore W2079557671C125619963 @default.
• W2079557671 hasConceptScore W2079557671C153911025 @default.
• W2079557671 hasConceptScore W2079557671C155064970 @default.
• W2079557671 hasConceptScore W2079557671C162008176 @default.
• W2079557671 hasConceptScore W2079557671C181199279 @default.
• W2079557671 hasConceptScore W2079557671C203663253 @default.
• W2079557671 hasConceptScore W2079557671C2778760513 @default.

• next