FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079562848> ?p ?o ?g. }

• W2079562848 endingPage "4340" @default.
• W2079562848 startingPage "4332" @default.
• W2079562848 abstract "The Ras family small GTPase Rap1 is activated by hematopoietic cytokines, such as interleukin (IL)-3, to induce beta1 integrin-mediated cell adhesion or by the BCR/ABL fusion tyrosine kinase to stimulate the MEK/Erk signaling pathway. Here, we demonstrate that the abrogation of Rap1 activation by SPA-1, a Rap1-specific GAP, inhibits activation of B-Raf, MEK, Erk, and Akt in a murine hematopoietic cell line, Ton.B210, stimulated with IL-3 or inducibly expressing BCR/ABL. Furthermore, Rap1 inactivation had an inhibitory effects on proliferation and survival of Ton.B210 cells, which were more remarkable when cells were stimulated by BCR/ABL than by IL-3. Induction of BCR/ABL expression increased adhesion of Ton.B210 cells to fibronectin in a manner at least partly dependent on its kinase activity, and Rap1 inhibition by SPA-1 partially inhibited BCR/ABL-induced adhesion of cells. Thus, IL-3- or BCR/ABL-induced activation of Rap1 may play important roles in regulation of cell proliferation and survival through activation of the B-Raf/MEK/Erk and Akt signaling pathways and in induction of integrin-mediated cell adhesion. Furthermore, as compared with IL-3, BCR/ABL is more dependent on Rap1-mediated signaling to induce cell proliferation and survival and, thus, Rap1 may represent an attractive target for novel therapies for leukemias caused by BCR/ABL." @default.
• W2079562848 created "2016-06-24" @default.
• W2079562848 creator A5024750099 @default.
• W2079562848 creator A5033388409 @default.
• W2079562848 creator A5038871110 @default.
• W2079562848 creator A5042787337 @default.
• W2079562848 creator A5069156257 @default.
• W2079562848 creator A5070831609 @default.
• W2079562848 creator A5074139458 @default.
• W2079562848 creator A5082415693 @default.
• W2079562848 creator A5086342547 @default.
• W2079562848 date "2006-03-06" @default.
• W2079562848 modified "2023-10-17" @default.
• W2079562848 title "BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion" @default.
• W2079562848 cites W1479698042 @default.
• W2079562848 cites W1598659248 @default.
• W2079562848 cites W1607113137 @default.
• W2079562848 cites W1836713718 @default.
• W2079562848 cites W1964445294 @default.
• W2079562848 cites W1964815717 @default.
• W2079562848 cites W1972146864 @default.
• W2079562848 cites W1973568352 @default.
• W2079562848 cites W1974632076 @default.
• W2079562848 cites W1982560959 @default.
• W2079562848 cites W1997098580 @default.
• W2079562848 cites W2009181525 @default.
• W2079562848 cites W2012806962 @default.
• W2079562848 cites W2017882961 @default.
• W2079562848 cites W2018988691 @default.
• W2079562848 cites W2023969596 @default.
• W2079562848 cites W2026624444 @default.
• W2079562848 cites W2027373844 @default.
• W2079562848 cites W2034900375 @default.
• W2079562848 cites W2037960492 @default.
• W2079562848 cites W2044838118 @default.
• W2079562848 cites W2046548078 @default.
• W2079562848 cites W2047922419 @default.
• W2079562848 cites W2057283586 @default.
• W2079562848 cites W2060092781 @default.
• W2079562848 cites W2073424135 @default.
• W2079562848 cites W2074089133 @default.
• W2079562848 cites W2075158125 @default.
• W2079562848 cites W2082580993 @default.
• W2079562848 cites W2083063047 @default.
• W2079562848 cites W2105248205 @default.
• W2079562848 cites W2111778006 @default.
• W2079562848 cites W2114857520 @default.
• W2079562848 cites W2125495844 @default.
• W2079562848 cites W2133683853 @default.
• W2079562848 cites W2147392364 @default.
• W2079562848 cites W2162664460 @default.
• W2079562848 cites W2166252375 @default.
• W2079562848 cites W2217357219 @default.
• W2079562848 cites W2314938037 @default.
• W2079562848 cites W2315508536 @default.
• W2079562848 cites W2335297539 @default.
• W2079562848 cites W2403941697 @default.
• W2079562848 cites W24291559 @default.
• W2079562848 cites W4243517959 @default.
• W2079562848 doi "https://doi.org/10.1038/sj.onc.1209459" @default.
• W2079562848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16518411" @default.
• W2079562848 hasPublicationYear "2006" @default.
• W2079562848 type Work @default.
• W2079562848 sameAs 2079562848 @default.
• W2079562848 citedByCount "49" @default.
• W2079562848 countsByYear W20795628482012 @default.
• W2079562848 countsByYear W20795628482013 @default.
• W2079562848 countsByYear W20795628482014 @default.
• W2079562848 countsByYear W20795628482015 @default.
• W2079562848 countsByYear W20795628482016 @default.
• W2079562848 countsByYear W20795628482017 @default.
• W2079562848 countsByYear W20795628482018 @default.
• W2079562848 countsByYear W20795628482019 @default.
• W2079562848 countsByYear W20795628482020 @default.
• W2079562848 countsByYear W20795628482022 @default.
• W2079562848 crossrefType "journal-article" @default.
• W2079562848 hasAuthorship W2079562848A5024750099 @default.
• W2079562848 hasAuthorship W2079562848A5033388409 @default.
• W2079562848 hasAuthorship W2079562848A5038871110 @default.
• W2079562848 hasAuthorship W2079562848A5042787337 @default.
• W2079562848 hasAuthorship W2079562848A5069156257 @default.
• W2079562848 hasAuthorship W2079562848A5070831609 @default.
• W2079562848 hasAuthorship W2079562848A5074139458 @default.
• W2079562848 hasAuthorship W2079562848A5082415693 @default.
• W2079562848 hasAuthorship W2079562848A5086342547 @default.
• W2079562848 hasBestOaLocation W20795628481 @default.
• W2079562848 hasConcept C1491633281 @default.
• W2079562848 hasConcept C170493617 @default.
• W2079562848 hasConcept C2776179587 @default.
• W2079562848 hasConcept C43907098 @default.
• W2079562848 hasConcept C502942594 @default.
• W2079562848 hasConcept C55493867 @default.
• W2079562848 hasConcept C57074206 @default.
• W2079562848 hasConcept C62478195 @default.
• W2079562848 hasConcept C75217442 @default.
• W2079562848 hasConcept C85789140 @default.
• W2079562848 hasConcept C86554907 @default.
• W2079562848 hasConcept C86803240 @default.

• next