FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079572206> ?p ?o ?g. }

• W2079572206 endingPage "468" @default.
• W2079572206 startingPage "459" @default.
• W2079572206 abstract "The major pathological processes of systemic scleroderma (SSc) comprise inflammation and microvascular damage in the early or acute progressive stage as well as tissue fibrosis and hypoxia in the chronic end stage. Fibrosis seems to be a general phenomenon characterized by an increase of hydroxylysine aldehyde derived collagen cross-links which has been shown in vitro for systemic scleroderma fibroblasts. In the present study, we analyzed the cross-link pattern and the gene expression of lysyl hydroxylase 2 (LH2) in the skin of SSc. Furthermore, we determined the modulatory impact of inflammatory cytokines (interleukin 4, TNF- alphaand interleukin 1alpha/beta) and prolonged hypoxia on the cross-link profile and the gene expression of LH2, respectively. The concentration of hydroxylysine aldehyde derived cross-links was significantly increased in SSc, while the level of lysine aldehyde derived cross-links was not changed. Accordingly, a marked increase of the transcriptional level of LH2 was found. In long term dermal fibroblast cultures, only interleukin 4 induced an increase of hydroxylysine aldehyde derived cross-links accompanied by a higher gene expression of LH2. Furthermore, prolonged hypoxia induced a marked increase of the mRNA level of LH2 in relation to collagen I. The skin of SSc is characterized by an increase of the transcriptional activity of LH2 leading to an altered cross-link pattern. The changes in the quality of the collagenous matrix can also be obtained in cell culture by the exposure of fibroblasts to interleukin 4 or prolonged hypoxia emphasizing the role of this mediator in the acute and the low oxygen tension in the chronic phase of the disease." @default.
• W2079572206 created "2016-06-24" @default.
• W2079572206 creator A5021458944 @default.
• W2079572206 creator A5031017191 @default.
• W2079572206 creator A5033004413 @default.
• W2079572206 creator A5042445931 @default.
• W2079572206 creator A5046636617 @default.
• W2079572206 creator A5054081182 @default.
• W2079572206 creator A5054159075 @default.
• W2079572206 creator A5071144290 @default.
• W2079572206 creator A5078749744 @default.
• W2079572206 creator A5087648838 @default.
• W2079572206 date "2005-10-01" @default.
• W2079572206 modified "2023-09-26" @default.
• W2079572206 title "Interleukin 4 and prolonged hypoxia induce a higher gene expression of lysyl hydroxylase 2 and an altered cross-link pattern: Important pathogenetic steps in early and late stage of systemic scleroderma?" @default.
• W2079572206 cites W1497601632 @default.
• W2079572206 cites W1513221428 @default.
• W2079572206 cites W1915025757 @default.
• W2079572206 cites W1968024679 @default.
• W2079572206 cites W1976782444 @default.
• W2079572206 cites W1980491111 @default.
• W2079572206 cites W1982297925 @default.
• W2079572206 cites W1982925783 @default.
• W2079572206 cites W1988605343 @default.
• W2079572206 cites W1989383397 @default.
• W2079572206 cites W1995677664 @default.
• W2079572206 cites W1997558531 @default.
• W2079572206 cites W2015423809 @default.
• W2079572206 cites W2016279537 @default.
• W2079572206 cites W2019967921 @default.
• W2079572206 cites W2021757059 @default.
• W2079572206 cites W2022405303 @default.
• W2079572206 cites W2042231871 @default.
• W2079572206 cites W2049706385 @default.
• W2079572206 cites W2057033794 @default.
• W2079572206 cites W2059545148 @default.
• W2079572206 cites W2065420949 @default.
• W2079572206 cites W2067377927 @default.
• W2079572206 cites W2070861861 @default.
• W2079572206 cites W2074391704 @default.
• W2079572206 cites W2075609837 @default.
• W2079572206 cites W2077411288 @default.
• W2079572206 cites W2080787252 @default.
• W2079572206 cites W2082366764 @default.
• W2079572206 cites W2084961147 @default.
• W2079572206 cites W2088280227 @default.
• W2079572206 cites W2097856339 @default.
• W2079572206 cites W2109534516 @default.
• W2079572206 cites W2125994830 @default.
• W2079572206 cites W2143222045 @default.
• W2079572206 cites W2147016321 @default.
• W2079572206 cites W2162992377 @default.
• W2079572206 cites W2166883265 @default.
• W2079572206 cites W2170487163 @default.
• W2079572206 cites W25497486 @default.
• W2079572206 cites W4247528220 @default.
• W2079572206 cites W4252699774 @default.
• W2079572206 doi "https://doi.org/10.1016/j.matbio.2005.07.002" @default.
• W2079572206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16139999" @default.
• W2079572206 hasPublicationYear "2005" @default.
• W2079572206 type Work @default.
• W2079572206 sameAs 2079572206 @default.
• W2079572206 citedByCount "59" @default.
• W2079572206 countsByYear W20795722062012 @default.
• W2079572206 countsByYear W20795722062013 @default.
• W2079572206 countsByYear W20795722062014 @default.
• W2079572206 countsByYear W20795722062015 @default.
• W2079572206 countsByYear W20795722062016 @default.
• W2079572206 countsByYear W20795722062017 @default.
• W2079572206 countsByYear W20795722062018 @default.
• W2079572206 countsByYear W20795722062019 @default.
• W2079572206 countsByYear W20795722062020 @default.
• W2079572206 countsByYear W20795722062021 @default.
• W2079572206 countsByYear W20795722062022 @default.
• W2079572206 countsByYear W20795722062023 @default.
• W2079572206 crossrefType "journal-article" @default.
• W2079572206 hasAuthorship W2079572206A5021458944 @default.
• W2079572206 hasAuthorship W2079572206A5031017191 @default.
• W2079572206 hasAuthorship W2079572206A5033004413 @default.
• W2079572206 hasAuthorship W2079572206A5042445931 @default.
• W2079572206 hasAuthorship W2079572206A5046636617 @default.
• W2079572206 hasAuthorship W2079572206A5054081182 @default.
• W2079572206 hasAuthorship W2079572206A5054159075 @default.
• W2079572206 hasAuthorship W2079572206A5071144290 @default.
• W2079572206 hasAuthorship W2079572206A5078749744 @default.
• W2079572206 hasAuthorship W2079572206A5087648838 @default.
• W2079572206 hasConcept C104317684 @default.
• W2079572206 hasConcept C126322002 @default.
• W2079572206 hasConcept C134018914 @default.
• W2079572206 hasConcept C150194340 @default.
• W2079572206 hasConcept C178790620 @default.
• W2079572206 hasConcept C180032290 @default.
• W2079572206 hasConcept C185592680 @default.
• W2079572206 hasConcept C202751555 @default.
• W2079572206 hasConcept C203014093 @default.
• W2079572206 hasConcept C2776016237 @default.
• W2079572206 hasConcept C2776252253 @default.
• W2079572206 hasConcept C2776661909 @default.

• next