FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079574459> ?p ?o ?g. }

• W2079574459 endingPage "1066" @default.
• W2079574459 startingPage "1056" @default.
• W2079574459 abstract "Aims Cinaciguat (BAY 58-2667) is a soluble guanylate cyclase (sGC) activator that, in a previous study among patients with acute heart failure syndromes (AHFS), improved pulmonary capillary wedge pressure (PCWP) at the expense of significant hypotension at doses ≥200 µg/h. The aim of the COMPOSE programme was to investigate the safety and efficacy of fixed, low doses of intravenous cinaciguat (<200 µg/h for 24–48 h) as add-on to standard therapy in adults hospitalized with AHFS. Methods and results COMPOSE comprised three randomized, double-blind, placebo-controlled studies in patients with [COMPOSE 1 and 2 (NCT01065077 and NCT01067859)] or without [COMPOSE EARLY (NCT01064037)] a requirement for invasive haemodynamic monitoring. COMPOSE 1 and COMPOSE EARLY assessed the effects of cinaciguat (50, 100, and 150 µg/h) on haemodynamics and dyspnoea, respectively. COMPOSE 2 assessed the haemodynamic effects of 10 and 25 µg/h cinaciguat. COMPOSE was terminated early due to an excess of non-fatal hypotension and recruitment difficulties. In COMPOSE 1 (n = 12), cinaciguat reduced PCWP at 8 h compared with placebo, but there was no relevant change in cardiac index. In COMPOSE EARLY (n = 62), no meaningful difference in dyspnoea was shown between cinaciguat and placebo. Conclusion In this limited database, short-term use of intravenous cinaciguat decreased blood pressure without improving dyspnoea or cardiac index. Given the lack of effect on dyspnoea and cardiac index and the hypotensive effect seen even with low doses, it is doubtful that further studies with intravenous cinaciguat would prove beneficial in this patient population." @default.
• W2079574459 created "2016-06-24" @default.
• W2079574459 creator A5000418035 @default.
• W2079574459 creator A5007432122 @default.
• W2079574459 creator A5011293667 @default.
• W2079574459 creator A5023320363 @default.
• W2079574459 creator A5028685517 @default.
• W2079574459 creator A5062655570 @default.
• W2079574459 creator A5079600079 @default.
• W2079574459 creator A5088186128 @default.
• W2079574459 creator A5091675945 @default.
• W2079574459 date "2012-09-01" @default.
• W2079574459 modified "2023-10-02" @default.
• W2079574459 title "Cinaciguat, a soluble guanylate cyclase activator: results from the randomized, controlled, phase IIb COMPOSE programme in acute heart failure syndromes" @default.
• W2079574459 cites W1968400561 @default.
• W2079574459 cites W1978717855 @default.
• W2079574459 cites W1979884788 @default.
• W2079574459 cites W1985227814 @default.
• W2079574459 cites W2003630942 @default.
• W2079574459 cites W2006806972 @default.
• W2079574459 cites W2014557512 @default.
• W2079574459 cites W2054183115 @default.
• W2079574459 cites W2069722675 @default.
• W2079574459 cites W2125353700 @default.
• W2079574459 cites W2141106625 @default.
• W2079574459 cites W2144133678 @default.
• W2079574459 cites W2147588039 @default.
• W2079574459 cites W2149641204 @default.
• W2079574459 cites W2164846898 @default.
• W2079574459 cites W2169631816 @default.
• W2079574459 cites W2171705903 @default.
• W2079574459 cites W2299836127 @default.
• W2079574459 cites W2326132384 @default.
• W2079574459 cites W2916505054 @default.
• W2079574459 cites W4206632929 @default.
• W2079574459 doi "https://doi.org/10.1093/eurjhf/hfs093" @default.
• W2079574459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22713287" @default.
• W2079574459 hasPublicationYear "2012" @default.
• W2079574459 type Work @default.
• W2079574459 sameAs 2079574459 @default.
• W2079574459 citedByCount "100" @default.
• W2079574459 countsByYear W20795744592012 @default.
• W2079574459 countsByYear W20795744592013 @default.
• W2079574459 countsByYear W20795744592014 @default.
• W2079574459 countsByYear W20795744592015 @default.
• W2079574459 countsByYear W20795744592016 @default.
• W2079574459 countsByYear W20795744592017 @default.
• W2079574459 countsByYear W20795744592018 @default.
• W2079574459 countsByYear W20795744592019 @default.
• W2079574459 countsByYear W20795744592020 @default.
• W2079574459 countsByYear W20795744592021 @default.
• W2079574459 countsByYear W20795744592022 @default.
• W2079574459 countsByYear W20795744592023 @default.
• W2079574459 crossrefType "journal-article" @default.
• W2079574459 hasAuthorship W2079574459A5000418035 @default.
• W2079574459 hasAuthorship W2079574459A5007432122 @default.
• W2079574459 hasAuthorship W2079574459A5011293667 @default.
• W2079574459 hasAuthorship W2079574459A5023320363 @default.
• W2079574459 hasAuthorship W2079574459A5028685517 @default.
• W2079574459 hasAuthorship W2079574459A5062655570 @default.
• W2079574459 hasAuthorship W2079574459A5079600079 @default.
• W2079574459 hasAuthorship W2079574459A5088186128 @default.
• W2079574459 hasAuthorship W2079574459A5091675945 @default.
• W2079574459 hasConcept C126322002 @default.
• W2079574459 hasConcept C139940330 @default.
• W2079574459 hasConcept C142724271 @default.
• W2079574459 hasConcept C146556889 @default.
• W2079574459 hasConcept C164705383 @default.
• W2079574459 hasConcept C168563851 @default.
• W2079574459 hasConcept C178853913 @default.
• W2079574459 hasConcept C204787440 @default.
• W2079574459 hasConcept C27081682 @default.
• W2079574459 hasConcept C2778198053 @default.
• W2079574459 hasConcept C2779295919 @default.
• W2079574459 hasConcept C31861589 @default.
• W2079574459 hasConcept C42219234 @default.
• W2079574459 hasConcept C71924100 @default.
• W2079574459 hasConcept C84393581 @default.
• W2079574459 hasConceptScore W2079574459C126322002 @default.
• W2079574459 hasConceptScore W2079574459C139940330 @default.
• W2079574459 hasConceptScore W2079574459C142724271 @default.
• W2079574459 hasConceptScore W2079574459C146556889 @default.
• W2079574459 hasConceptScore W2079574459C164705383 @default.
• W2079574459 hasConceptScore W2079574459C168563851 @default.
• W2079574459 hasConceptScore W2079574459C178853913 @default.
• W2079574459 hasConceptScore W2079574459C204787440 @default.
• W2079574459 hasConceptScore W2079574459C27081682 @default.
• W2079574459 hasConceptScore W2079574459C2778198053 @default.
• W2079574459 hasConceptScore W2079574459C2779295919 @default.
• W2079574459 hasConceptScore W2079574459C31861589 @default.
• W2079574459 hasConceptScore W2079574459C42219234 @default.
• W2079574459 hasConceptScore W2079574459C71924100 @default.
• W2079574459 hasConceptScore W2079574459C84393581 @default.
• W2079574459 hasIssue "9" @default.
• W2079574459 hasLocation W20795744591 @default.
• W2079574459 hasLocation W20795744592 @default.
• W2079574459 hasOpenAccess W2079574459 @default.
• W2079574459 hasPrimaryLocation W20795744591 @default.

• next