Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079577054> ?p ?o ?g. }
- W2079577054 endingPage "80" @default.
- W2079577054 startingPage "72" @default.
- W2079577054 abstract "Each skeletal muscle contains a fixed ratio of fast and slow myofibers that are distributed in a stereotyped pattern to achieve a specific motor function. How myofibers are specified during development and regeneration is poorly understood. Here we address this question using transgenic reporter mice that indelibly mark the myofiber lineages based on activation of fast or slow myosin. Lineage tracing indicates that during development all muscles have activated the fast myosin gene Myl1, but not the slow myosin gene Myh7, which is activated in all slow but a subset of fast myofibers. Similarly, most nascent myofibers do not activate Myh7 during fast muscle regeneration, but the ratio and pattern of fast and slow myofibers are restored at the completion of regeneration. At the single myofiber level, most mature fast myofibers are heterogeneous in nuclear composition, manifested by mosaic activation of Myh7. Strikingly, Myh7 is activated in a subpopulation of proliferating myoblasts that co-express the myogenic progenitor marker Pax7. When induced to differentiate, the Myh7-activated myoblasts differentiate more readily than the non-activated myoblasts, and have a higher tendency, but not restricted, to become slow myotubes. Together, our data reveal significant nuclear heterogeneity within a single myofiber, and challenge the conventional view that myosin genes are only expressed after myogenic differentiation. These results provide novel insights into the regulation of muscle fiber type specification." @default.
- W2079577054 created "2016-06-24" @default.
- W2079577054 creator A5015584667 @default.
- W2079577054 creator A5020422316 @default.
- W2079577054 creator A5046531172 @default.
- W2079577054 creator A5055838753 @default.
- W2079577054 creator A5061594246 @default.
- W2079577054 creator A5081900779 @default.
- W2079577054 creator A5091102272 @default.
- W2079577054 date "2015-06-01" @default.
- W2079577054 modified "2023-10-16" @default.
- W2079577054 title "Heterogeneous activation of a slow myosin gene in proliferating myoblasts and differentiated single myofibers" @default.
- W2079577054 cites W1975933947 @default.
- W2079577054 cites W1978032840 @default.
- W2079577054 cites W1979255869 @default.
- W2079577054 cites W1987030748 @default.
- W2079577054 cites W1990031010 @default.
- W2079577054 cites W1996885736 @default.
- W2079577054 cites W1997245748 @default.
- W2079577054 cites W1999382103 @default.
- W2079577054 cites W2009100350 @default.
- W2079577054 cites W2011640487 @default.
- W2079577054 cites W2013464812 @default.
- W2079577054 cites W2021037171 @default.
- W2079577054 cites W2036145275 @default.
- W2079577054 cites W2043123806 @default.
- W2079577054 cites W2052306269 @default.
- W2079577054 cites W2070032418 @default.
- W2079577054 cites W2085648653 @default.
- W2079577054 cites W2089577900 @default.
- W2079577054 cites W2094078534 @default.
- W2079577054 cites W2104010513 @default.
- W2079577054 cites W2104135721 @default.
- W2079577054 cites W2118942329 @default.
- W2079577054 cites W2130025116 @default.
- W2079577054 cites W2134193049 @default.
- W2079577054 cites W2136563400 @default.
- W2079577054 cites W2138313400 @default.
- W2079577054 cites W2151037856 @default.
- W2079577054 cites W2170601648 @default.
- W2079577054 cites W2176715668 @default.
- W2079577054 doi "https://doi.org/10.1016/j.ydbio.2015.02.025" @default.
- W2079577054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4435531" @default.
- W2079577054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25794679" @default.
- W2079577054 hasPublicationYear "2015" @default.
- W2079577054 type Work @default.
- W2079577054 sameAs 2079577054 @default.
- W2079577054 citedByCount "16" @default.
- W2079577054 countsByYear W20795770542016 @default.
- W2079577054 countsByYear W20795770542017 @default.
- W2079577054 countsByYear W20795770542018 @default.
- W2079577054 countsByYear W20795770542019 @default.
- W2079577054 countsByYear W20795770542020 @default.
- W2079577054 countsByYear W20795770542021 @default.
- W2079577054 countsByYear W20795770542022 @default.
- W2079577054 crossrefType "journal-article" @default.
- W2079577054 hasAuthorship W2079577054A5015584667 @default.
- W2079577054 hasAuthorship W2079577054A5020422316 @default.
- W2079577054 hasAuthorship W2079577054A5046531172 @default.
- W2079577054 hasAuthorship W2079577054A5055838753 @default.
- W2079577054 hasAuthorship W2079577054A5061594246 @default.
- W2079577054 hasAuthorship W2079577054A5081900779 @default.
- W2079577054 hasAuthorship W2079577054A5091102272 @default.
- W2079577054 hasBestOaLocation W20795770542 @default.
- W2079577054 hasConcept C171056886 @default.
- W2079577054 hasConcept C207200792 @default.
- W2079577054 hasConcept C3763915 @default.
- W2079577054 hasConcept C6997183 @default.
- W2079577054 hasConcept C74581901 @default.
- W2079577054 hasConcept C8035138 @default.
- W2079577054 hasConcept C86803240 @default.
- W2079577054 hasConcept C95444343 @default.
- W2079577054 hasConceptScore W2079577054C171056886 @default.
- W2079577054 hasConceptScore W2079577054C207200792 @default.
- W2079577054 hasConceptScore W2079577054C3763915 @default.
- W2079577054 hasConceptScore W2079577054C6997183 @default.
- W2079577054 hasConceptScore W2079577054C74581901 @default.
- W2079577054 hasConceptScore W2079577054C8035138 @default.
- W2079577054 hasConceptScore W2079577054C86803240 @default.
- W2079577054 hasConceptScore W2079577054C95444343 @default.
- W2079577054 hasFunder F4320306114 @default.
- W2079577054 hasFunder F4320332161 @default.
- W2079577054 hasIssue "1" @default.
- W2079577054 hasLocation W20795770541 @default.
- W2079577054 hasLocation W20795770542 @default.
- W2079577054 hasLocation W20795770543 @default.
- W2079577054 hasLocation W20795770544 @default.
- W2079577054 hasOpenAccess W2079577054 @default.
- W2079577054 hasPrimaryLocation W20795770541 @default.
- W2079577054 hasRelatedWork W160186609 @default.
- W2079577054 hasRelatedWork W1975926948 @default.
- W2079577054 hasRelatedWork W2043191111 @default.
- W2079577054 hasRelatedWork W2079577054 @default.
- W2079577054 hasRelatedWork W2092743085 @default.
- W2079577054 hasRelatedWork W2131192326 @default.
- W2079577054 hasRelatedWork W2131467977 @default.
- W2079577054 hasRelatedWork W2164615927 @default.
- W2079577054 hasRelatedWork W241142681 @default.