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- W2079580040 abstract "Bovine heart cytochrome c oxidase and related heme copper oxidases are inhibited by cyanide, which binds at the binuclear heme-a3/CuB site where dioxygen is reduced to water. To determine the mode of cyanide binding, heme-based binuclear complexes containing iron−cyanide−copper bridges in different oxidation states have been prepared by the reaction of [(py)(OEP)Fe(CN)] with Cu(II,I) precursors and structurally characterized by X-ray methods. Structures of two precursor complexes and two binuclear CuI−CN−CuI species are reported. The assembly [(py)(OEP)Fe−CN−Cu(Npy3)]2+ has a nearly linear FeIII−CN−CuII bridge containing low-spin Fe(III). The assemblies [(OEP)Fe−NC−Cu(MeNpy2)]+ and [(OEP−CH2CN)Fe−NC−Cu(Npy3)]+ exhibit the high-spin bridges FeIII−NC−CuI and FeII−NC−CuI, respectively. These are the first title bridges in these oxidation states. Bridge atom sequences are obtained from structural refinements of both linkage isomers; those for the reduced bridges are consistent with the soft-acid nature of Cu(I). Cyanide stretching frequencies respond to metal oxidation state and bridge geometry and, using data for solution and solid states, fall into the following ranges: FeIII−CN−CuII, 2120−2184 cm-1 (11 examples); FeIII−NC−CuI, 2072−2100 cm-1 (2 examples); FeII−NC−CuI, 2099−2107 cm-1 (1 example). These data are compared with νCN values for the enzymes in different oxidation states. A nonlinear FeIII−CN−CuII bridge (Cu−N−C = 150−160°) is consistent with the 2146−2152 cm-1 range found for the fully oxidized enzymes. Bands that can be assigned with some certainty as Fe−CN vibrations in partially and fully reduced enzymes do not appear to correspond to FeIII−NC−CuI and FeII−NC−CuI bridges but rather to FeII−CN modes. The current work complements and extends our previous investigation (Scott and Holm, J. Am. Chem. Soc. 1994, 116, 11357) of linear and nonlinear FeIII−CN−CuII bridges and is part of an investigation directed at providing a molecular basis of cyanide toxicity. (MeNpy2 = bis(2-(2-pyridylethyl))methylamine; Npy3 = tris(2-pyridylmethyl)amine; OEP = octaethylporphyrinate(2−), OEP−CH2CN = N-(cyanomethyl)octaethylporphyrinate(1−).)" @default.
- W2079580040 created "2016-06-24" @default.
- W2079580040 creator A5003617517 @default.
- W2079580040 creator A5052881048 @default.
- W2079580040 date "1998-08-25" @default.
- W2079580040 modified "2023-10-16" @default.
- W2079580040 title "Molecular Heme−Cyanide−Copper Bridged Assemblies: Linkage Isomerism, Trends in ν<sub>CN</sub> Values, and Relation to the Heme-<i>a</i><sub>3</sub>/Cu<sub>B</sub> Site in Cyanide-Inhibited Heme−Copper Oxidases" @default.
- W2079580040 cites W1485800824 @default.
- W2079580040 cites W1500810353 @default.
- W2079580040 cites W1508734769 @default.
- W2079580040 cites W1509420079 @default.
- W2079580040 cites W1549096372 @default.
- W2079580040 cites W1565005789 @default.
- W2079580040 cites W1571201200 @default.
- W2079580040 cites W1580750254 @default.
- W2079580040 cites W1634486319 @default.
- W2079580040 cites W1966105433 @default.
- W2079580040 cites W1967888351 @default.
- W2079580040 cites W1971246384 @default.
- W2079580040 cites W1974572661 @default.
- W2079580040 cites W1978474869 @default.
- W2079580040 cites W1979672106 @default.
- W2079580040 cites W1981261075 @default.
- W2079580040 cites W1984253162 @default.
- W2079580040 cites W1996200934 @default.
- W2079580040 cites W1996827593 @default.
- W2079580040 cites W1997076231 @default.
- W2079580040 cites W2000539534 @default.
- W2079580040 cites W2001784797 @default.
- W2079580040 cites W2002468278 @default.
- W2079580040 cites W2009653969 @default.
- W2079580040 cites W2011093366 @default.
- W2079580040 cites W2014499171 @default.
- W2079580040 cites W2016393657 @default.
- W2079580040 cites W2016719253 @default.
- W2079580040 cites W2017647691 @default.
- W2079580040 cites W2019602059 @default.
- W2079580040 cites W2021948228 @default.
- W2079580040 cites W2022791936 @default.
- W2079580040 cites W2028000772 @default.
- W2079580040 cites W2038525877 @default.
- W2079580040 cites W2040008296 @default.
- W2079580040 cites W2040410883 @default.
- W2079580040 cites W2041315640 @default.
- W2079580040 cites W2041622967 @default.
- W2079580040 cites W2042883148 @default.
- W2079580040 cites W2046226490 @default.
- W2079580040 cites W2046552363 @default.
- W2079580040 cites W2047722528 @default.
- W2079580040 cites W2056747623 @default.
- W2079580040 cites W2056802581 @default.
- W2079580040 cites W2063155755 @default.
- W2079580040 cites W2063941057 @default.
- W2079580040 cites W2067791558 @default.
- W2079580040 cites W2071278571 @default.
- W2079580040 cites W2072471396 @default.
- W2079580040 cites W2078251643 @default.
- W2079580040 cites W2079108392 @default.
- W2079580040 cites W2079971827 @default.
- W2079580040 cites W2079983963 @default.
- W2079580040 cites W2081413659 @default.
- W2079580040 cites W2083505041 @default.
- W2079580040 cites W2083909100 @default.
- W2079580040 cites W2088929728 @default.
- W2079580040 cites W2089461286 @default.
- W2079580040 cites W2091934527 @default.
- W2079580040 cites W2093001905 @default.
- W2079580040 cites W2131145780 @default.
- W2079580040 cites W2150264392 @default.
- W2079580040 cites W2154158126 @default.
- W2079580040 cites W2227807977 @default.
- W2079580040 cites W2314963153 @default.
- W2079580040 cites W2345438321 @default.
- W2079580040 cites W2419518843 @default.
- W2079580040 cites W2949725671 @default.
- W2079580040 cites W2951145553 @default.
- W2079580040 cites W2952795296 @default.
- W2079580040 cites W41313 @default.
- W2079580040 cites W4235830858 @default.
- W2079580040 cites W4318444835 @default.
- W2079580040 doi "https://doi.org/10.1021/ic9801793" @default.
- W2079580040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11670655" @default.
- W2079580040 hasPublicationYear "1998" @default.
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