Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079580176> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2079580176 endingPage "105" @default.
- W2079580176 startingPage "95" @default.
- W2079580176 abstract "Cellular regeneration and tissue repair greatly influence the outcome of acute carbon tetrachloride (CCl4) hepatotoxicity. This study examined the temporal kinetics of cellular regeneration and tissue repair processes in male and female Sprague Dawley (SD) rats following an acute CCl4 exposure (0.8 ml/kg, i.p.). In female rats, hepatic damage peaked at 24 h following the treatment and was approximately 2.5-fold (AST 2.7-fold, ALT 2.3 fold) greater than the damage observed in male rats. The hepatic damage in male rats appeared to peak by 3 h post-exposure and did not significantly change through the 36-h time-point. The activity of cytochrome P 4502E1 was 20% greater in male rats and did not correlate with the magnitude of hepatic damage. Morphometric analysis of cell cycle indices revealed that cellular regeneration was significantly greater in female rats as compared to male rats at 48 h and corresponded proportionally to the extent of liver damage. This study demonstrated that female SD rats respond more severely to acute CCl4 hepatotoxicity than male SD rats and the extent of tissue repair and cellular regeneration was greater in female rats. Furthermore, our results suggest that tissue repair is unlikely to result in accounting for the different responses exhibited by male and female SD rats to CCl4 hepatotoxicity." @default.
- W2079580176 created "2016-06-24" @default.
- W2079580176 creator A5018837936 @default.
- W2079580176 creator A5024583758 @default.
- W2079580176 creator A5034826967 @default.
- W2079580176 date "1998-09-01" @default.
- W2079580176 modified "2023-09-30" @default.
- W2079580176 title "Evaluation of sex difference in tissue repair following acute carbon tetrachloride toxicity in male and female Sprague–Dawley rats" @default.
- W2079580176 cites W1554913031 @default.
- W2079580176 cites W1966238235 @default.
- W2079580176 cites W1969980050 @default.
- W2079580176 cites W2014780926 @default.
- W2079580176 cites W2015176029 @default.
- W2079580176 cites W2018639193 @default.
- W2079580176 cites W2025665586 @default.
- W2079580176 cites W2053705594 @default.
- W2079580176 cites W2056636760 @default.
- W2079580176 cites W2060641804 @default.
- W2079580176 cites W2073672761 @default.
- W2079580176 cites W2084929175 @default.
- W2079580176 cites W2091790310 @default.
- W2079580176 cites W2097092416 @default.
- W2079580176 cites W2138690160 @default.
- W2079580176 cites W2152604676 @default.
- W2079580176 cites W65409542 @default.
- W2079580176 doi "https://doi.org/10.1016/s0300-483x(98)00095-x" @default.
- W2079580176 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9865477" @default.
- W2079580176 hasPublicationYear "1998" @default.
- W2079580176 type Work @default.
- W2079580176 sameAs 2079580176 @default.
- W2079580176 citedByCount "16" @default.
- W2079580176 countsByYear W20795801762015 @default.
- W2079580176 countsByYear W20795801762018 @default.
- W2079580176 countsByYear W20795801762020 @default.
- W2079580176 countsByYear W20795801762022 @default.
- W2079580176 countsByYear W20795801762023 @default.
- W2079580176 crossrefType "journal-article" @default.
- W2079580176 hasAuthorship W2079580176A5018837936 @default.
- W2079580176 hasAuthorship W2079580176A5024583758 @default.
- W2079580176 hasAuthorship W2079580176A5034826967 @default.
- W2079580176 hasConcept C102124568 @default.
- W2079580176 hasConcept C126322002 @default.
- W2079580176 hasConcept C134018914 @default.
- W2079580176 hasConcept C16685009 @default.
- W2079580176 hasConcept C171056886 @default.
- W2079580176 hasConcept C178790620 @default.
- W2079580176 hasConcept C185592680 @default.
- W2079580176 hasConcept C2776795407 @default.
- W2079580176 hasConcept C2777359374 @default.
- W2079580176 hasConcept C29730261 @default.
- W2079580176 hasConcept C2992176824 @default.
- W2079580176 hasConcept C3017497123 @default.
- W2079580176 hasConcept C71924100 @default.
- W2079580176 hasConcept C86803240 @default.
- W2079580176 hasConcept C95444343 @default.
- W2079580176 hasConceptScore W2079580176C102124568 @default.
- W2079580176 hasConceptScore W2079580176C126322002 @default.
- W2079580176 hasConceptScore W2079580176C134018914 @default.
- W2079580176 hasConceptScore W2079580176C16685009 @default.
- W2079580176 hasConceptScore W2079580176C171056886 @default.
- W2079580176 hasConceptScore W2079580176C178790620 @default.
- W2079580176 hasConceptScore W2079580176C185592680 @default.
- W2079580176 hasConceptScore W2079580176C2776795407 @default.
- W2079580176 hasConceptScore W2079580176C2777359374 @default.
- W2079580176 hasConceptScore W2079580176C29730261 @default.
- W2079580176 hasConceptScore W2079580176C2992176824 @default.
- W2079580176 hasConceptScore W2079580176C3017497123 @default.
- W2079580176 hasConceptScore W2079580176C71924100 @default.
- W2079580176 hasConceptScore W2079580176C86803240 @default.
- W2079580176 hasConceptScore W2079580176C95444343 @default.
- W2079580176 hasIssue "2-3" @default.
- W2079580176 hasLocation W20795801761 @default.
- W2079580176 hasLocation W20795801762 @default.
- W2079580176 hasOpenAccess W2079580176 @default.
- W2079580176 hasPrimaryLocation W20795801761 @default.
- W2079580176 hasRelatedWork W2029822823 @default.
- W2079580176 hasRelatedWork W2060641804 @default.
- W2079580176 hasRelatedWork W207674387 @default.
- W2079580176 hasRelatedWork W2079580176 @default.
- W2079580176 hasRelatedWork W2085499642 @default.
- W2079580176 hasRelatedWork W2324458213 @default.
- W2079580176 hasRelatedWork W2357794170 @default.
- W2079580176 hasRelatedWork W2384169544 @default.
- W2079580176 hasRelatedWork W2407814576 @default.
- W2079580176 hasRelatedWork W93427940 @default.
- W2079580176 hasVolume "130" @default.
- W2079580176 isParatext "false" @default.
- W2079580176 isRetracted "false" @default.
- W2079580176 magId "2079580176" @default.
- W2079580176 workType "article" @default.