Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079581129> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2079581129 endingPage "374" @default.
- W2079581129 startingPage "370" @default.
- W2079581129 abstract "Chronic cutaneous graft-versus-host disease (GvHD) can arise as a late complication after allogeneic bone marrow transplantation. Patients with extensive disease to date require intensive early and long-term immunosuppression; however, treatment is often insufficient. Since the beneficial effects of phototherapy for chronic cutaneous GvHD are well known, extracorporeal photoimmunotherapy (ECP) was also tried with some success for a few single patients with this disease.The long-term effect of ECP was evaluated in 4 patients with therapy-resistant severe chronic cutaneous GvHD after allogeneic bone marrow transplantation.Four patients were treated with monthly sessions of ECP over a period of 16-40 months. Disease severity was assessed by a semiquantitative score adapted from the literature including extent of skin area involved, rigidity of the skin, involvement of joints and immunosuppressive drug consumption.In all patients, a favorable response was observed after 6-12 treatment cycles. One patient had a complete response, 2 patients had a partial response, and 1 patient had a minor response after treatment. In 2 patients, immunosuppressive medication started before initiating ECP could be reduced or completely withdrawn under ECP. Peripheral blood lymphocyte immunophenotyping revealed reduction of CD3+ CD4+ T cells in 3 patients and of elevated CD3+ CD8+ and CD57+ CD8+ T cell subsets in 2 patients.ECP is effective in treating severe chronic cutaneous GvHD. ECP possibly exerts its effects by reducing the number of CD8+ suppressor/cytotoxic T cells, the presumptive effector cells of GvHD. ECP is well tolerated with essentially no side effects and allows reducing the dosage of immunosuppressive agents." @default.
- W2079581129 created "2016-06-24" @default.
- W2079581129 creator A5013410369 @default.
- W2079581129 creator A5036246537 @default.
- W2079581129 creator A5076386746 @default.
- W2079581129 date "1999-01-01" @default.
- W2079581129 modified "2023-09-25" @default.
- W2079581129 title "Long-Term Extracorporeal Photoimmunotherapy for Treatment of Chronic Cutaneous Graft-versus-Host Disease: Observations in Four Patients" @default.
- W2079581129 cites W135072596 @default.
- W2079581129 cites W1539774679 @default.
- W2079581129 cites W1597077777 @default.
- W2079581129 cites W17521658 @default.
- W2079581129 cites W1981972362 @default.
- W2079581129 cites W1985494755 @default.
- W2079581129 cites W2000706093 @default.
- W2079581129 cites W2014543561 @default.
- W2079581129 cites W2018052299 @default.
- W2079581129 cites W2022638963 @default.
- W2079581129 cites W2025229215 @default.
- W2079581129 cites W2029117355 @default.
- W2079581129 cites W2048658292 @default.
- W2079581129 cites W2053278212 @default.
- W2079581129 cites W2055860284 @default.
- W2079581129 cites W2070176050 @default.
- W2079581129 cites W2071466688 @default.
- W2079581129 cites W2075294206 @default.
- W2079581129 cites W2088935309 @default.
- W2079581129 cites W2090191181 @default.
- W2079581129 cites W2094292853 @default.
- W2079581129 cites W2142213162 @default.
- W2079581129 cites W2159149803 @default.
- W2079581129 cites W2333657038 @default.
- W2079581129 cites W2337557724 @default.
- W2079581129 cites W2394562640 @default.
- W2079581129 cites W2406577470 @default.
- W2079581129 cites W2418784837 @default.
- W2079581129 cites W62438283 @default.
- W2079581129 cites W86597909 @default.
- W2079581129 doi "https://doi.org/10.1159/000018150" @default.
- W2079581129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10449936" @default.
- W2079581129 hasPublicationYear "1999" @default.
- W2079581129 type Work @default.
- W2079581129 sameAs 2079581129 @default.
- W2079581129 citedByCount "17" @default.
- W2079581129 countsByYear W20795811292012 @default.
- W2079581129 countsByYear W20795811292013 @default.
- W2079581129 countsByYear W20795811292014 @default.
- W2079581129 countsByYear W20795811292017 @default.
- W2079581129 countsByYear W20795811292020 @default.
- W2079581129 countsByYear W20795811292023 @default.
- W2079581129 crossrefType "journal-article" @default.
- W2079581129 hasAuthorship W2079581129A5013410369 @default.
- W2079581129 hasAuthorship W2079581129A5036246537 @default.
- W2079581129 hasAuthorship W2079581129A5076386746 @default.
- W2079581129 hasConcept C141071460 @default.
- W2079581129 hasConcept C167672396 @default.
- W2079581129 hasConcept C203014093 @default.
- W2079581129 hasConcept C2779972918 @default.
- W2079581129 hasConcept C2780252810 @default.
- W2079581129 hasConcept C2780648854 @default.
- W2079581129 hasConcept C2909962264 @default.
- W2079581129 hasConcept C2911091166 @default.
- W2079581129 hasConcept C71924100 @default.
- W2079581129 hasConcept C8891405 @default.
- W2079581129 hasConcept C90924648 @default.
- W2079581129 hasConceptScore W2079581129C141071460 @default.
- W2079581129 hasConceptScore W2079581129C167672396 @default.
- W2079581129 hasConceptScore W2079581129C203014093 @default.
- W2079581129 hasConceptScore W2079581129C2779972918 @default.
- W2079581129 hasConceptScore W2079581129C2780252810 @default.
- W2079581129 hasConceptScore W2079581129C2780648854 @default.
- W2079581129 hasConceptScore W2079581129C2909962264 @default.
- W2079581129 hasConceptScore W2079581129C2911091166 @default.
- W2079581129 hasConceptScore W2079581129C71924100 @default.
- W2079581129 hasConceptScore W2079581129C8891405 @default.
- W2079581129 hasConceptScore W2079581129C90924648 @default.
- W2079581129 hasIssue "4" @default.
- W2079581129 hasLocation W20795811291 @default.
- W2079581129 hasLocation W20795811292 @default.
- W2079581129 hasOpenAccess W2079581129 @default.
- W2079581129 hasPrimaryLocation W20795811291 @default.
- W2079581129 hasRelatedWork W1872714075 @default.
- W2079581129 hasRelatedWork W1981908249 @default.
- W2079581129 hasRelatedWork W2014564023 @default.
- W2079581129 hasRelatedWork W2034766142 @default.
- W2079581129 hasRelatedWork W2041041327 @default.
- W2079581129 hasRelatedWork W204558573 @default.
- W2079581129 hasRelatedWork W2086542836 @default.
- W2079581129 hasRelatedWork W2136175148 @default.
- W2079581129 hasRelatedWork W2152802537 @default.
- W2079581129 hasRelatedWork W3048820708 @default.
- W2079581129 hasVolume "198" @default.
- W2079581129 isParatext "false" @default.
- W2079581129 isRetracted "false" @default.
- W2079581129 magId "2079581129" @default.
- W2079581129 workType "article" @default.