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- W2079581201 abstract "Agents that alkylate DNA in the minor groove are potent cytotoxins. Together with their potential sequence selectivity of interaction with DNA, they are therefore of great interest as potential anticancer drugs. Work with nitrogen mustards has shown that attachment of the mustard unit to carrier molecules targeted at the minor groove can drastically alter normal patterns of both regio- and sequence-selectivity of alkylation, from reaction primarily at most guanine N7 sites in the major groove (chlorambucil) to a few adenine N3 sites at the 3’-end of poly(A/T) sequences in the minor groove (tallimustine). Similar targeting of pyrrolizidine alkylators has also been reported. However, most recent (1997 - 1999) patent applications in this area have been focused on the cyclopropaindolone class of natural products which alkylate at the N-3 of adenines in runs of adenines." @default.
- W2079581201 created "2016-06-24" @default.
- W2079581201 creator A5023901201 @default.
- W2079581201 date "2000-04-01" @default.
- W2079581201 modified "2023-09-24" @default.
- W2079581201 title "DNA minor groove alkylating agents" @default.
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- W2079581201 doi "https://doi.org/10.1517/13543776.10.4.459" @default.
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