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• W2079581619 abstract "The basolateral complex of the amygdala (BLA) is uniquely affected by steroid hormones. Whereas glucocorticoids (GCs)--the adrenal hormones released during stress--increase the excitability of BLA neurons, estrogen decreases it.In this study, we used a vector designed to express a chimeric gene that contains the GC-binding domain of the GC receptor (GR) and the DNA binding domain of the estrogen receptor (ER) (ER/GR) in infected neurons; as a result, it transduces GC signals into estrogenic ones. We microinfused ER/GR bilaterally into the BLA of rats to determine whether it would impair fear conditioning, a valuable BLA-dependent paradigm for studying the neural basis of emotional memory.Expression of ER/GR in the BLA caused robust expression of the transgene and a significant disruption of both auditory and contextual long-term fear memory consolidation, whereas fear learning and post-shock freezing remained intact.These data show that dual gene therapy with ER/GR might be a useful tool for understanding the role of steroid hormones in the storage of traumatic memories." @default.
• W2079581619 created "2016-06-24" @default.
• W2079581619 creator A5048552038 @default.
• W2079581619 creator A5072175765 @default.
• W2079581619 date "2009-03-01" @default.
• W2079581619 modified "2023-09-24" @default.
• W2079581619 title "Disruption of Fear Memory Through Dual-Hormone Gene Therapy" @default.
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• W2079581619 doi "https://doi.org/10.1016/j.biopsych.2008.09.003" @default.
• W2079581619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2660393" @default.
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