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• W2079583019 abstract "A number of biochemical processes rely on isoprenoids, including the post-translational modification of signaling proteins and the biosynthesis of a wide array of compounds. Photoactivatable analogues have been developed to study isoprenoid utilizing enzymes such as the isoprenoid synthases and prenyltransferases. While these initial analogues proved to be excellent structural analogues with good cross-linking capability, they lack the stability needed when the goals include isolation of cross-linked species, tryptic digestion, and subsequent peptide sequencing. Here, the synthesis of a benzophenone-based farnesyl diphosphate analogue containing a stable phosphonophosphate group is described. Inhibition kinetics, photolabeling experiments, as well as X-ray crystallographic analysis with a protein prenyltransferase are described, verifying this compound as a good isoprenoid mimetic. In addition, the utility of this new analogue was explored by using it to photoaffinity label crude protein extracts obtained from Hevea brasiliensis latex. Those experiments suggest that a small protein, rubber elongation factor, interacts directly with farnesyl diphosphate during rubber biosynthesis. These results indicate that this benzophenone-based isoprenoid analogue will be useful for identifying enzymes that utilize farnesyl diphosphate as a substrate." @default.
• W2079583019 created "2016-06-24" @default.
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• W2079583019 date "2007-05-04" @default.
• W2079583019 modified "2023-10-16" @default.
• W2079583019 title "A Photoactive Isoprenoid Diphosphate Analogue Containing a Stable Phosphonate Linkage: Synthesis and Biochemical Studies with Prenyltransferases" @default.
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• W2079583019 doi "https://doi.org/10.1021/jo0623033" @default.
• W2079583019 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2561318" @default.
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• W2079583019 hasPublicationYear "2007" @default.
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