Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079583451> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2079583451 endingPage "831" @default.
- W2079583451 startingPage "821" @default.
- W2079583451 abstract "Abstract The respiratory control and rate of oxidation of exogenous NADH in vitro by liver mitochondria from vitamin E deficient rats were studied as a means of providing information concerning possible mitochondrial membrane alterations due to the deficiency. When mitochondria were aged at different temperatures for various periods of time, half-maximal inhibition of respiratory control occurred at lower temperatures and shorter aging periods in deficient mitochondria than in normal ones. Also, respiratory control was lost more rapidly in deficient mitochondria than in normal ones in the presence of either digitonin or low (hypotonic) concentrations of mannitol. Microsomes, both freshly prepared and boiled, dramatically lowered respiratory control and the effect was greater in the deficient mitochondria. Bovine serum albumin overcame the suppressed respiratory control, and exogenously added fatty acids mimiced the action of the microsomes. NADH oxidation by normal mitochondria proceeded slowly in isotonic media, while mitochondria of vitamin E deficient rats oxidized NADH much more rapidly. When mitochondria were subjected to ultrasonic disruption or incubated in hypotonic media, the rates of NADH oxidation by both types of mitochondria were similar. Respiratory decline associated with oxidation of β-hydroxybutyrate by the deficient mitochondria was decreased by including in the medium either a high concentration of NAD + , 0.5 m m oxalacetate, or 2 m m aspartate plus 1 m m α-ketoglutarate. This observation, plus the finding of similar activities of malate dehydrogenase and glutamic-oxalacetic transminase in normal and deficient livers, suggests that the action of each was due to an elevation of the mitochondrial NAD + /NADH ratio via a malate shuttle and cytoplasmic and mitochondrial glutamic-oxalacetate transaminase. It is postulated that the marked mitochondrial respiratory decline in the deficient rats is attributed to a limiting availability of NAD + and a low ratio of NAD + to NADH." @default.
- W2079583451 created "2016-06-24" @default.
- W2079583451 creator A5003005547 @default.
- W2079583451 creator A5011234995 @default.
- W2079583451 date "1973-12-01" @default.
- W2079583451 modified "2023-09-26" @default.
- W2079583451 title "Vitamin E deficiency in the rat. IV. Alteration in mitochondrial membrane and its relation to respiratory decline" @default.
- W2079583451 cites W1490107603 @default.
- W2079583451 cites W1505163202 @default.
- W2079583451 cites W1512170777 @default.
- W2079583451 cites W1516204830 @default.
- W2079583451 cites W1519453872 @default.
- W2079583451 cites W1551173757 @default.
- W2079583451 cites W1559673845 @default.
- W2079583451 cites W1569800944 @default.
- W2079583451 cites W157290466 @default.
- W2079583451 cites W1575852352 @default.
- W2079583451 cites W158673942 @default.
- W2079583451 cites W1775749144 @default.
- W2079583451 cites W1801184284 @default.
- W2079583451 cites W1961777745 @default.
- W2079583451 cites W2012309427 @default.
- W2079583451 cites W2038498153 @default.
- W2079583451 cites W2067277017 @default.
- W2079583451 cites W4238979623 @default.
- W2079583451 cites W46718529 @default.
- W2079583451 cites W47194553 @default.
- W2079583451 cites W4780316 @default.
- W2079583451 doi "https://doi.org/10.1016/0003-9861(73)90523-7" @default.
- W2079583451 hasPublicationYear "1973" @default.
- W2079583451 type Work @default.
- W2079583451 sameAs 2079583451 @default.
- W2079583451 citedByCount "14" @default.
- W2079583451 crossrefType "journal-article" @default.
- W2079583451 hasAuthorship W2079583451A5003005547 @default.
- W2079583451 hasAuthorship W2079583451A5011234995 @default.
- W2079583451 hasConcept C105702510 @default.
- W2079583451 hasConcept C134018914 @default.
- W2079583451 hasConcept C185592680 @default.
- W2079583451 hasConcept C25343380 @default.
- W2079583451 hasConcept C2776940978 @default.
- W2079583451 hasConcept C28859421 @default.
- W2079583451 hasConcept C41008148 @default.
- W2079583451 hasConcept C42407357 @default.
- W2079583451 hasConcept C534529494 @default.
- W2079583451 hasConcept C55493867 @default.
- W2079583451 hasConcept C75385678 @default.
- W2079583451 hasConcept C77088390 @default.
- W2079583451 hasConcept C86803240 @default.
- W2079583451 hasConceptScore W2079583451C105702510 @default.
- W2079583451 hasConceptScore W2079583451C134018914 @default.
- W2079583451 hasConceptScore W2079583451C185592680 @default.
- W2079583451 hasConceptScore W2079583451C25343380 @default.
- W2079583451 hasConceptScore W2079583451C2776940978 @default.
- W2079583451 hasConceptScore W2079583451C28859421 @default.
- W2079583451 hasConceptScore W2079583451C41008148 @default.
- W2079583451 hasConceptScore W2079583451C42407357 @default.
- W2079583451 hasConceptScore W2079583451C534529494 @default.
- W2079583451 hasConceptScore W2079583451C55493867 @default.
- W2079583451 hasConceptScore W2079583451C75385678 @default.
- W2079583451 hasConceptScore W2079583451C77088390 @default.
- W2079583451 hasConceptScore W2079583451C86803240 @default.
- W2079583451 hasIssue "2" @default.
- W2079583451 hasLocation W20795834511 @default.
- W2079583451 hasOpenAccess W2079583451 @default.
- W2079583451 hasPrimaryLocation W20795834511 @default.
- W2079583451 hasRelatedWork W1523953204 @default.
- W2079583451 hasRelatedWork W1968692725 @default.
- W2079583451 hasRelatedWork W1981501348 @default.
- W2079583451 hasRelatedWork W2071566197 @default.
- W2079583451 hasRelatedWork W2084009799 @default.
- W2079583451 hasRelatedWork W2085586146 @default.
- W2079583451 hasRelatedWork W2109348501 @default.
- W2079583451 hasRelatedWork W2128659575 @default.
- W2079583451 hasRelatedWork W2465198420 @default.
- W2079583451 hasRelatedWork W2185536029 @default.
- W2079583451 hasVolume "159" @default.
- W2079583451 isParatext "false" @default.
- W2079583451 isRetracted "false" @default.
- W2079583451 magId "2079583451" @default.
- W2079583451 workType "article" @default.