FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079583991> ?p ?o ?g. }

• W2079583991 endingPage "709" @default.
• W2079583991 startingPage "699" @default.
• W2079583991 abstract "Interferon regulatory factor-1 (IRF-1) is a transcription factor that acts as a tumor suppressor and causes apoptosis in cancer cells. We evaluated IRF-1-induced apoptosis in gastric cancer cell lines. We established stable clones in AGS cells that have a tetracycline-inducible IRF-1 expression system. We used these clones and recombinant adenovirus expressing IRF-1 to explore the mechanism of IRF-1-induced apoptosis in gastric cancer. Expression of IRF-1 causes apoptosis in gastric cancer cell lines as shown by phosphatidylserine exposure and cleavage of caspase-8, caspase-3, and Bid with the mitochondrial release of cytochrome c. However, inhibition of caspase-8 and Bid did not inhibit apoptosis and did not decrease cleaved caspase-9 or mitochondrial release of cytochrome c. We then show that IRF-1 upregulates PUMA (p53 upregulated modulator of apoptosis), which is known to activate apoptosis by the intrinsic pathway; this can be p53-independent. IRF-1 binds to distinct sites in the promoter of PUMA and activates PUMA transcription. Moreover, molecular markers of mitochondrial apoptosis are eliminated in PUMA knockout and knockdown cells and phosphatidylserine exposure is decreased dramatically. Finally, we show that IFN-gamma induces IRF-1-mediated upregulation of PUMA in cancer cells. We conclude that IRF-1 can induce apoptosis by the intrinsic pathway independent of the extrinsic pathway by upregulation of PUMA." @default.
• W2079583991 created "2016-06-24" @default.
• W2079583991 creator A5028963094 @default.
• W2079583991 creator A5032538286 @default.
• W2079583991 creator A5041831958 @default.
• W2079583991 creator A5045580244 @default.
• W2079583991 creator A5053870799 @default.
• W2079583991 creator A5084197958 @default.
• W2079583991 creator A5086910766 @default.
• W2079583991 creator A5089457025 @default.
• W2079583991 date "2009-10-23" @default.
• W2079583991 modified "2023-10-16" @default.
• W2079583991 title "IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells" @default.
• W2079583991 cites W1510578593 @default.
• W2079583991 cites W1567072634 @default.
• W2079583991 cites W1942214720 @default.
• W2079583991 cites W1971321073 @default.
• W2079583991 cites W1978813721 @default.
• W2079583991 cites W1990017150 @default.
• W2079583991 cites W1995037299 @default.
• W2079583991 cites W2001653597 @default.
• W2079583991 cites W2006354480 @default.
• W2079583991 cites W2029493522 @default.
• W2079583991 cites W2032603938 @default.
• W2079583991 cites W2047677971 @default.
• W2079583991 cites W2050761539 @default.
• W2079583991 cites W2056839147 @default.
• W2079583991 cites W2070692423 @default.
• W2079583991 cites W2075062521 @default.
• W2079583991 cites W2076566451 @default.
• W2079583991 cites W2089082314 @default.
• W2079583991 cites W2097397907 @default.
• W2079583991 cites W2114078657 @default.
• W2079583991 cites W2119885778 @default.
• W2079583991 cites W2128985829 @default.
• W2079583991 cites W2147640266 @default.
• W2079583991 cites W2147862373 @default.
• W2079583991 cites W2147881852 @default.
• W2079583991 cites W2148355109 @default.
• W2079583991 cites W2148397698 @default.
• W2079583991 cites W2154852632 @default.
• W2079583991 doi "https://doi.org/10.1038/cdd.2009.156" @default.
• W2079583991 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2838929" @default.
• W2079583991 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19851330" @default.
• W2079583991 hasPublicationYear "2009" @default.
• W2079583991 type Work @default.
• W2079583991 sameAs 2079583991 @default.
• W2079583991 citedByCount "68" @default.
• W2079583991 countsByYear W20795839912012 @default.
• W2079583991 countsByYear W20795839912013 @default.
• W2079583991 countsByYear W20795839912014 @default.
• W2079583991 countsByYear W20795839912015 @default.
• W2079583991 countsByYear W20795839912016 @default.
• W2079583991 countsByYear W20795839912017 @default.
• W2079583991 countsByYear W20795839912018 @default.
• W2079583991 countsByYear W20795839912019 @default.
• W2079583991 countsByYear W20795839912020 @default.
• W2079583991 countsByYear W20795839912021 @default.
• W2079583991 countsByYear W20795839912022 @default.
• W2079583991 countsByYear W20795839912023 @default.
• W2079583991 crossrefType "journal-article" @default.
• W2079583991 hasAuthorship W2079583991A5028963094 @default.
• W2079583991 hasAuthorship W2079583991A5032538286 @default.
• W2079583991 hasAuthorship W2079583991A5041831958 @default.
• W2079583991 hasAuthorship W2079583991A5045580244 @default.
• W2079583991 hasAuthorship W2079583991A5053870799 @default.
• W2079583991 hasAuthorship W2079583991A5084197958 @default.
• W2079583991 hasAuthorship W2079583991A5086910766 @default.
• W2079583991 hasAuthorship W2079583991A5089457025 @default.
• W2079583991 hasBestOaLocation W20795839912 @default.
• W2079583991 hasConcept C104317684 @default.
• W2079583991 hasConcept C121608353 @default.
• W2079583991 hasConcept C12519072 @default.
• W2079583991 hasConcept C127561419 @default.
• W2079583991 hasConcept C153911025 @default.
• W2079583991 hasConcept C170301204 @default.
• W2079583991 hasConcept C173396325 @default.
• W2079583991 hasConcept C185592680 @default.
• W2079583991 hasConcept C190283241 @default.
• W2079583991 hasConcept C2777417711 @default.
• W2079583991 hasConcept C2778918659 @default.
• W2079583991 hasConcept C2779637612 @default.
• W2079583991 hasConcept C28859421 @default.
• W2079583991 hasConcept C29311851 @default.
• W2079583991 hasConcept C31573885 @default.
• W2079583991 hasConcept C41625074 @default.
• W2079583991 hasConcept C48297814 @default.
• W2079583991 hasConcept C502942594 @default.
• W2079583991 hasConcept C54009773 @default.
• W2079583991 hasConcept C54355233 @default.
• W2079583991 hasConcept C81885089 @default.
• W2079583991 hasConcept C86803240 @default.
• W2079583991 hasConcept C91096171 @default.
• W2079583991 hasConcept C95444343 @default.
• W2079583991 hasConcept C96232424 @default.
• W2079583991 hasConcept C98424977 @default.
• W2079583991 hasConceptScore W2079583991C104317684 @default.
• W2079583991 hasConceptScore W2079583991C121608353 @default.

• next