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• W2079585537 abstract "Exposure of V79 Chinese hamster cells to a single very low (sub-toxic and sub-clastogenic) dose of MNU or MNNG made these cells resistant to the toxic, mutagenic and clastogenic activities of the same agents given 6 h later. Cell survival was increased nearly 2-fold under optimal conditions when compared with the non-pretreated controls. Aberration frequencies were reduced to nearly half the control values (cells not pretreated). This was observed for a wide range of pretreatment concentrations and at different recovery times. The effect of mutagen pretreatment was most pronounced with respect to the induction of TG resistance, which became drastically reduced. The data indicate the existence of an adaptive repair pathway in V79 cells which may be induced by very low levels of methylating agents and which is error-free in handling lesions responsible, at least partially, for reproductive cell death, mutations and chromosomal aberrations." @default.
• W2079585537 created "2016-06-24" @default.
• W2079585537 creator A5026593378 @default.
• W2079585537 date "1982-03-01" @default.
• W2079585537 modified "2023-09-30" @default.
• W2079585537 title "Enhanced survival and reduced mutation and aberration frequencies induced in 79 Chinese hamster cells pre-exposed to low levels of methylating agents" @default.
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• W2079585537 doi "https://doi.org/10.1016/0027-5107(82)90135-x" @default.
• W2079585537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7062931" @default.
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