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• W2079585616 abstract "Fever is an important part of the host defense response, yet fever can be detrimental if it is uncontrolled. We provide the first evidence that 15-deoxy-Δ 12,14 -prostaglandin J 2 (15d-PGJ 2 ), an endogenous ligand for peroxisome proliferator-activated receptor γ (PPARγ), can attenuate the febrile response to lipopolysaccharide (LPS) in rats via an action on the brain. Furthermore, we show that PPARγ is expressed in the hypothalamus, an important locus in the brain for fever generation. In addition, 15d-PGJ 2 and its synthesizing enzyme (PGD 2 synthase) were present in rat cerebrospinal fluid, and their levels were enhanced in response to systemic injection of LPS. The antipyretic effect of 15d-PGJ 2 was associated with reduction in LPS-stimulated cyclooxygenase-2 expression in the hypothalamus but not in p44/p42 mitogen-activated protein kinase phosphorylation or in the expression of the PPARγ. Thus it is likely that there is a parallel induction of an endogenous prostanoid pathway in the brain capable of limiting deleterious actions of the proinflammatory prostaglandin E 2 -dependent pathway." @default.
• W2079585616 created "2016-06-24" @default.
• W2079585616 creator A5019840028 @default.
• W2079585616 creator A5078941490 @default.
• W2079585616 creator A5083233470 @default.
• W2079585616 date "2004-02-11" @default.
• W2079585616 modified "2023-10-15" @default.
• W2079585616 title "A Novel Antipyretic Action of 15-Deoxy-Δ^12,14-Prostaglandin J₂in the Rat Brain" @default.
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• W2079585616 doi "https://doi.org/10.1523/jneurosci.3145-03.2004" @default.
• W2079585616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6730345" @default.
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