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- W2079585758 abstract "Surface plasmon resonance (SPR) offers a method of biophysical fragment screening that is fast, efficient, cost effective and accurate. SPR is increasingly being adopted as a secondary assay to validate fragment hits. Recently, technical advances have resulted in the emergence of SPR as a primary screening methodology for fragment-based drug discovery. Moreover, SPR biosensor assays can be developed for a wide range of proteins, including membrane proteins, such as G-protein-coupled receptors. In this review, we discuss the advantages and limitations of SPR fragment screening including experimental consideration of reducing false positive and false negative rates to a minimum. We discuss how ligand efficiency can be used both as a method to eliminate false positives and to understand which fragments in a library may be a source of false negatives." @default.
- W2079585758 created "2016-06-24" @default.
- W2079585758 creator A5017647626 @default.
- W2079585758 creator A5076759117 @default.
- W2079585758 date "2011-10-01" @default.
- W2079585758 modified "2023-09-26" @default.
- W2079585758 title "Emerging role of surface plasmon resonance in fragment-based drug discovery" @default.
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- W2079585758 doi "https://doi.org/10.4155/fmc.11.128" @default.
- W2079585758 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22004086" @default.
- W2079585758 hasPublicationYear "2011" @default.
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