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- W2079587210 abstract "Ritanserin, a 5-HT2 receptor antagonist, was injected intraperitoneally to rats at light onset. It was found that 0.63 mg/kg decreased waking, increased the slow waves characteristic of the first stage of sleep, and decreased paradoxical sleep (PS) during the first four hours. Active waking was further decreased and slow wave stage increased during the following four hours. The number of synchronized and paradoxical sleep phases decreased whereas their duration increased during the first four hours. Ritanserin at 2.5 mg/kg decreased active waking and PS, whereas quiet waking and slow wave stage were increased during the first four hours. Quiet waking was increased during the following four hours. It is concluded that serotonin acting on 5 HT2 receptors is actively involved in sleep-waking regulation." @default.
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- W2079587210 date "1992-01-01" @default.
- W2079587210 modified "2023-09-29" @default.
- W2079587210 title "Study of the 5-HT2 antagonist ritanserin on sleep-waking cycle in the rat" @default.
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- W2079587210 doi "https://doi.org/10.1016/0091-3057(92)90091-s" @default.
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