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- W2079587630 abstract "Abstract Eight-month-old male New Zealand white rabbits were fed a diet of 2% cholesterol and 6% corn oil mixed with rabbit chow. One group of rabbits, previously reported, (and called the group) was kept on the diet, and groups of 6 animals killed at each of 4, 8, and 10 weeks. The other group, reported here, (and called the group) was fed the cholesterol and corn oil diet for 4 weeks, and then returned to rabbit chow. Six animals in this group were killed at 2, 6, and 12 weeks after cessation of the cholesterol diet. Serum cholesterols were measured in all animals at 4 weeks and at killing. The aortas were removed, stained with Sudan III, pinned at in situ dimensions, and mapped with the polar coordinate method. Most of the lesions in the group were periorificial, and increased gradually with time on the diet, and as the serum cholesterol rose. In the group, the periorificial lesions grew more rapidly than in the group, and, in addition, many lesions developed away from the orifices, and then continued to increase even after the periorificial lesions started to regress after 12 weeks off the diet. The shape of the periorificial lesions changed dramatically as started. No significant fibrous tissue developed. Hemodynamic factors appear to play less role in the regression than in the progression group." @default.
- W2079587630 created "2016-06-24" @default.
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- W2079587630 date "1979-01-01" @default.
- W2079587630 modified "2023-09-26" @default.
- W2079587630 title "Alterations in distribution of sudanophilic lesions in rabbits after cessation of a cholesterol-rich diet" @default.
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- W2079587630 doi "https://doi.org/10.1016/0021-9150(79)90141-2" @default.
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