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• W2079587735 abstract "Programmed cell death 1 (PD-1) is an inducible immune modulatory receptor. Upon interaction with its ligands B7 homolog 1 (PD-L1) and B7-DC (PD-L2), PD-1 plays important roles in negative regulation of T cell responses to antigen stimulation and maintaining peripheral tolerance. In addition to the inducible expression pattern on conventional T cells, PD-1 is also found on regulatory T cells, follicular T and B cells, and antigen-presenting cells including activated dendritic cells and monocytes. Therefore, PD-1 may have a much broader functionality than expected in negative regulation of multiple arms of immune responses. In addition to cancer therapy, the manipulation of PD-1 and its ligands may hold great promise for therapeutic applications also in autoimmune and infectious diseases." @default.
• W2079587735 created "2016-06-24" @default.
• W2079587735 creator A5035295243 @default.
• W2079587735 creator A5062637798 @default.
• W2079587735 date "2014-07-01" @default.
• W2079587735 modified "2023-09-26" @default.
• W2079587735 title "PD-1 as an Immune Modulatory Receptor" @default.
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• W2079587735 doi "https://doi.org/10.1097/ppo.0000000000000060" @default.
• W2079587735 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4455017" @default.
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