Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079589423> ?p ?o ?g. }
- W2079589423 endingPage "37" @default.
- W2079589423 startingPage "30" @default.
- W2079589423 abstract "The amyloid precursor protein (APP) and its cellular processing are believed to be centrally involved in the etiology of Alzheimer’s disease (AD). In addition, many physiological functions have been described for APP, including a role in cell–cell- and cell–ECM-adhesion as well as in axonal outgrowth. We show here the molecular determinants of the oligomerization/dimerization of APP, which is central for its cellular (mis)function. Using size exclusion chromatography (SEC), dynamic light scattering and SEC-coupled static light scattering we demonstrate that the dimerization of APP is energetically induced by a heparin mediated dimerization of the E1 domain, which results in a dimeric interaction of E2. We also show that the acidic domain (AcD) interferes with the dimerization of E1 and propose a model where both, cis- and trans-dimerization occur dependent on cellular localization and function." @default.
- W2079589423 created "2016-06-24" @default.
- W2079589423 creator A5006952070 @default.
- W2079589423 creator A5009754094 @default.
- W2079589423 creator A5029915766 @default.
- W2079589423 creator A5058531177 @default.
- W2079589423 creator A5083534192 @default.
- W2079589423 creator A5085545646 @default.
- W2079589423 date "2014-07-01" @default.
- W2079589423 modified "2023-09-30" @default.
- W2079589423 title "Heparin induced dimerization of APP is primarily mediated by E1 and regulated by its acidic domain" @default.
- W2079589423 cites W1600007560 @default.
- W2079589423 cites W1812970642 @default.
- W2079589423 cites W1932612562 @default.
- W2079589423 cites W1964305847 @default.
- W2079589423 cites W1965633082 @default.
- W2079589423 cites W1966617266 @default.
- W2079589423 cites W1968675059 @default.
- W2079589423 cites W1968900405 @default.
- W2079589423 cites W1971856927 @default.
- W2079589423 cites W1982067620 @default.
- W2079589423 cites W1986892064 @default.
- W2079589423 cites W1987201286 @default.
- W2079589423 cites W1987403479 @default.
- W2079589423 cites W1988927287 @default.
- W2079589423 cites W1988986946 @default.
- W2079589423 cites W1994681896 @default.
- W2079589423 cites W1994841747 @default.
- W2079589423 cites W1998177934 @default.
- W2079589423 cites W2004644288 @default.
- W2079589423 cites W2007810468 @default.
- W2079589423 cites W2012920180 @default.
- W2079589423 cites W2021118737 @default.
- W2079589423 cites W2023965625 @default.
- W2079589423 cites W2028213861 @default.
- W2079589423 cites W2030249003 @default.
- W2079589423 cites W2045855955 @default.
- W2079589423 cites W2047172988 @default.
- W2079589423 cites W2055091636 @default.
- W2079589423 cites W2057126031 @default.
- W2079589423 cites W2059440801 @default.
- W2079589423 cites W2065319195 @default.
- W2079589423 cites W2066958493 @default.
- W2079589423 cites W2067445072 @default.
- W2079589423 cites W2079400095 @default.
- W2079589423 cites W2095521702 @default.
- W2079589423 cites W2096492508 @default.
- W2079589423 cites W2102556796 @default.
- W2079589423 cites W2102673346 @default.
- W2079589423 cites W2132695172 @default.
- W2079589423 cites W2141583120 @default.
- W2079589423 cites W2154815136 @default.
- W2079589423 cites W2169152986 @default.
- W2079589423 cites W4211156109 @default.
- W2079589423 doi "https://doi.org/10.1016/j.jsb.2014.05.006" @default.
- W2079589423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24859793" @default.
- W2079589423 hasPublicationYear "2014" @default.
- W2079589423 type Work @default.
- W2079589423 sameAs 2079589423 @default.
- W2079589423 citedByCount "24" @default.
- W2079589423 countsByYear W20795894232015 @default.
- W2079589423 countsByYear W20795894232016 @default.
- W2079589423 countsByYear W20795894232017 @default.
- W2079589423 countsByYear W20795894232018 @default.
- W2079589423 countsByYear W20795894232019 @default.
- W2079589423 countsByYear W20795894232020 @default.
- W2079589423 countsByYear W20795894232021 @default.
- W2079589423 countsByYear W20795894232022 @default.
- W2079589423 countsByYear W20795894232023 @default.
- W2079589423 crossrefType "journal-article" @default.
- W2079589423 hasAuthorship W2079589423A5006952070 @default.
- W2079589423 hasAuthorship W2079589423A5009754094 @default.
- W2079589423 hasAuthorship W2079589423A5029915766 @default.
- W2079589423 hasAuthorship W2079589423A5058531177 @default.
- W2079589423 hasAuthorship W2079589423A5083534192 @default.
- W2079589423 hasAuthorship W2079589423A5085545646 @default.
- W2079589423 hasBestOaLocation W20795894231 @default.
- W2079589423 hasConcept C12554922 @default.
- W2079589423 hasConcept C134306372 @default.
- W2079589423 hasConcept C14036430 @default.
- W2079589423 hasConcept C142724271 @default.
- W2079589423 hasConcept C14631669 @default.
- W2079589423 hasConcept C1491633281 @default.
- W2079589423 hasConcept C155672457 @default.
- W2079589423 hasConcept C171250308 @default.
- W2079589423 hasConcept C179104552 @default.
- W2079589423 hasConcept C185592680 @default.
- W2079589423 hasConcept C192562407 @default.
- W2079589423 hasConcept C2777633098 @default.
- W2079589423 hasConcept C2779134260 @default.
- W2079589423 hasConcept C31705614 @default.
- W2079589423 hasConcept C33923547 @default.
- W2079589423 hasConcept C36503486 @default.
- W2079589423 hasConcept C502032728 @default.
- W2079589423 hasConcept C55493867 @default.
- W2079589423 hasConcept C71924100 @default.
- W2079589423 hasConcept C85789140 @default.
- W2079589423 hasConcept C86803240 @default.