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- W2079589735 abstract "<h3>Abstract</h3> Glia contribute to synapse elimination through phagocytosis in the central nervous system. Despite important roles during development and neurological disorders, the “eat-me” signal that initiates glia-mediated phagocytosis of synapses remains largely elusive. Here, by generating inducible conditional knockout mice of <i>Cdc50a</i>, we induced stable exposure of phosphatidylserine in the neuronal outer membrane. Surprisingly, acute <i>Cdc50a</i> deletion in neurons causes specific loss of inhibitory post-synapses without affecting other synapses, thereby generating excessive excitability with appearance of seizure. Ablating microglia or deleting microglial <i>Mertk</i> rescues the loss of inhibitory post-synapses, indicating that microglial phagocytosis is responsible for inhibitory post-synapse elimination. Moreover, inhibitory post-synapses in normal juvenile brains also use phosphatidylserine for synapse pruning by microglia, suggesting that phosphatidylserine may serve as a general “eat-me” signal for inhibitory post-synapse elimination. <h3>One Sentence Summary</h3> <i>Cdc50a</i> dependent phosphatidylserine exposure functions as an “eat-me” signal for microglia-dependent inhibitory post-synapse elimination" @default.
- W2079589735 created "2016-06-24" @default.
- W2079589735 creator A5001150955 @default.
- W2079589735 date "2010-09-24" @default.
- W2079589735 modified "2023-09-25" @default.
- W2079589735 title "UN summit launches new initiative for women and children's health" @default.
- W2079589735 doi "https://doi.org/10.1136/bmj.c5276" @default.
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- W2079589735 hasPublicationYear "2010" @default.
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