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• W2079590230 startingPage "385" @default.
• W2079590230 abstract "BDNF, Dopamine, and Cocaine Reward The nucleus accumbens plays a crucial role in mediating the rewarding effects of drugs of abuse. Different subpopulations of nucleus accumbens projection neurons exhibit balanced but antagonistic influences on their downstream outputs and behaviors. However, their roles in regulating reward behaviors remains unclear. Lobo et al. (p. 385 ) evaluated the roles of the two subtypes of nucleus accumbens projection neurons, those expressing dopamine D1 versus D2 receptors, in cocaine reward. Deleting TrkB, the receptor for brain-derived neurotrophic factor, selectively in each cell type, and selectively controlling the firing of each cell type using optogenetic techniques allowed for confirmation that D1- and D2-containing neurons produced opposite effects on cocaine reward." @default.
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• W2079590230 date "2010-10-15" @default.
• W2079590230 modified "2023-10-16" @default.
• W2079590230 title "Cell Type–Specific Loss of BDNF Signaling Mimics Optogenetic Control of Cocaine Reward" @default.
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• W2079590230 doi "https://doi.org/10.1126/science.1188472" @default.
• W2079590230 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3011229" @default.
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• W2079590230 hasPublicationYear "2010" @default.
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