FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079591756> ?p ?o ?g. }

• W2079591756 endingPage "1412" @default.
• W2079591756 startingPage "1405" @default.
• W2079591756 abstract "In eukaryotes, the 3' ends of RNA polymerase II-transcribed RNAs are generated in the majority of cases by site-specific endonucleolytic cleavage, followed by the addition of a poly(A) tail. Through alternative polyadenylation, a gene can give rise to multiple mRNA isoforms that differ in the length of their 3' UTRs and hence in their susceptibility to post-transcriptional regulatory factors such as microRNAs. A series of recently conducted high-throughput studies of poly(A) site usage revealed an extensive tissue-specific control and drastic changes in the length of mRNA 3' UTRs upon induction of proliferation in resting cells. To understand the dynamics of poly(A) site choice, we recently identified binding sites of the major pre-mRNA 3' end processing factors - cleavage and polyadenylation specificity factor (CPSF), cleavage stimulation factor (CstF), and cleavage factor Im (CF Im) - and mapped polyadenylation sites in HEK293 cells. Our present study extends previous findings on the role of CF Im in alternative polyadenylation and reveals that subunits of the CF Im complex generally control 3' UTR length. More specifically, we demonstrate that the loss-of-function of CF Im 68 and CF Im 25 but not of CF Im 59 leads to a transcriptome-wide increase in the use of proximal polyadenylation sites in HEK293 cells." @default.
• W2079591756 created "2016-06-24" @default.
• W2079591756 creator A5018588101 @default.
• W2079591756 creator A5034442754 @default.
• W2079591756 creator A5046060796 @default.
• W2079591756 creator A5046091216 @default.
• W2079591756 date "2012-12-01" @default.
• W2079591756 modified "2023-10-17" @default.
• W2079591756 title "Cleavage factor I_mis a key regulator of 3′ UTR length" @default.
• W2079591756 cites W1539247107 @default.
• W2079591756 cites W1553081734 @default.
• W2079591756 cites W1964727443 @default.
• W2079591756 cites W1967959947 @default.
• W2079591756 cites W1981898947 @default.
• W2079591756 cites W1984594593 @default.
• W2079591756 cites W1991230146 @default.
• W2079591756 cites W1994563059 @default.
• W2079591756 cites W1994803330 @default.
• W2079591756 cites W2019815305 @default.
• W2079591756 cites W2020652334 @default.
• W2079591756 cites W2021561259 @default.
• W2079591756 cites W2021678907 @default.
• W2079591756 cites W2022046147 @default.
• W2079591756 cites W2026168910 @default.
• W2079591756 cites W2027403969 @default.
• W2079591756 cites W2028446861 @default.
• W2079591756 cites W2029069592 @default.
• W2079591756 cites W2032184093 @default.
• W2079591756 cites W2035631777 @default.
• W2079591756 cites W2038424676 @default.
• W2079591756 cites W2043158983 @default.
• W2079591756 cites W2052418876 @default.
• W2079591756 cites W2052494348 @default.
• W2079591756 cites W2053003053 @default.
• W2079591756 cites W2063151549 @default.
• W2079591756 cites W2065213545 @default.
• W2079591756 cites W2082102894 @default.
• W2079591756 cites W2084813257 @default.
• W2079591756 cites W2089029993 @default.
• W2079591756 cites W2093295511 @default.
• W2079591756 cites W2093827499 @default.
• W2079591756 cites W2095930993 @default.
• W2079591756 cites W2106774938 @default.
• W2079591756 cites W2108712105 @default.
• W2079591756 cites W2114532236 @default.
• W2079591756 cites W2118031210 @default.
• W2079591756 cites W2118834857 @default.
• W2079591756 cites W2132640619 @default.
• W2079591756 cites W2146521441 @default.
• W2079591756 cites W2170669858 @default.
• W2079591756 cites W2171791048 @default.
• W2079591756 doi "https://doi.org/10.4161/rna.22570" @default.
• W2079591756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23187700" @default.
• W2079591756 hasPublicationYear "2012" @default.
• W2079591756 type Work @default.
• W2079591756 sameAs 2079591756 @default.
• W2079591756 citedByCount "123" @default.
• W2079591756 countsByYear W20795917562013 @default.
• W2079591756 countsByYear W20795917562014 @default.
• W2079591756 countsByYear W20795917562015 @default.
• W2079591756 countsByYear W20795917562016 @default.
• W2079591756 countsByYear W20795917562017 @default.
• W2079591756 countsByYear W20795917562018 @default.
• W2079591756 countsByYear W20795917562019 @default.
• W2079591756 countsByYear W20795917562020 @default.
• W2079591756 countsByYear W20795917562021 @default.
• W2079591756 countsByYear W20795917562022 @default.
• W2079591756 countsByYear W20795917562023 @default.
• W2079591756 crossrefType "journal-article" @default.
• W2079591756 hasAuthorship W2079591756A5018588101 @default.
• W2079591756 hasAuthorship W2079591756A5034442754 @default.
• W2079591756 hasAuthorship W2079591756A5046060796 @default.
• W2079591756 hasAuthorship W2079591756A5046091216 @default.
• W2079591756 hasBestOaLocation W20795917561 @default.
• W2079591756 hasConcept C104317684 @default.
• W2079591756 hasConcept C105580179 @default.
• W2079591756 hasConcept C133672593 @default.
• W2079591756 hasConcept C142575336 @default.
• W2079591756 hasConcept C145059251 @default.
• W2079591756 hasConcept C151730666 @default.
• W2079591756 hasConcept C153911025 @default.
• W2079591756 hasConcept C175156509 @default.
• W2079591756 hasConcept C22232683 @default.
• W2079591756 hasConcept C22667442 @default.
• W2079591756 hasConcept C41282012 @default.
• W2079591756 hasConcept C43369102 @default.
• W2079591756 hasConcept C53345823 @default.
• W2079591756 hasConcept C54355233 @default.
• W2079591756 hasConcept C62531158 @default.
• W2079591756 hasConcept C67492840 @default.
• W2079591756 hasConcept C86339819 @default.
• W2079591756 hasConcept C86803240 @default.
• W2079591756 hasConcept C89604277 @default.
• W2079591756 hasConcept C95444343 @default.
• W2079591756 hasConceptScore W2079591756C104317684 @default.
• W2079591756 hasConceptScore W2079591756C105580179 @default.
• W2079591756 hasConceptScore W2079591756C133672593 @default.
• W2079591756 hasConceptScore W2079591756C142575336 @default.

• next