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- W2079592194 abstract "SLICES of rat cingulate cortex, when incubated in magnesium-free medium, produce spontaneous epileptiform spikes. Here it is demonstrated that the metabotropic glutamate receptor (mGluR) agonists ± trans-1-amino-cyclopentane-1,3-dicarboxylic acid (± Trans-ACPD), IS3R-ACPD and quisqualic acid (quis) can reduce the frequency of these bursts in a concentration-dependent manner. The IC50 values were 16, 12 and 26 μM, respectively. The low concentrations of ± trans- and IS3R-ACPD used, plus the lack of NMDA antagonism shown by these compounds, suggest that the effect may be via a presynaptic reduction in glutamate release. The relative potency of the agonists IS3R-ACPD > Trans-ACPD > quis would seem to suggest that the mGluR1 receptor is not involved." @default.
- W2079592194 created "2016-06-24" @default.
- W2079592194 creator A5010705387 @default.
- W2079592194 date "1992-10-01" @default.
- W2079592194 modified "2023-10-18" @default.
- W2079592194 title "Metabotropic glutamate receptor agonists reduce epileptiform activity in the rat cortex" @default.
- W2079592194 doi "https://doi.org/10.1097/00001756-199210000-00024" @default.
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