Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079594443> ?p ?o ?g. }
- W2079594443 endingPage "82" @default.
- W2079594443 startingPage "76" @default.
- W2079594443 abstract "Summary Tripterygium wilfordii Hook.f. ( TWHF ) has a long history as a T raditional C hinese M edicine ( TCM ) herb that aids in treating inflammatory and autoimmune diseases. The major bioactive component of TWHF is triptolide, which has been recognized to possess a broad spectrum of biological profiles including antiinflammatory, immunosuppressive, antifertility, and antitumor activities, as well as neurotrophic and neuroprotective effects. Limitation of triptolide, such as poor water solubility and severe systemic toxicity, has postponed clinical development and trials; however, the wide range of medicinal value of triptolide has been drawing intensive worldwide attention. In particular, triptolide has been shown to have significant effects on central nervous system ( CNS ) diseases, such as P arkinson's disease, Alzheimer's disease, spinal cord and brain injury, and multiple sclerosis. This review focuses on the potential therapeutic role of triptolide on CNS diseases, and discusses the structural features, potential modifications, and the other pharmacological activities of triptolide." @default.
- W2079594443 created "2016-06-24" @default.
- W2079594443 creator A5055875257 @default.
- W2079594443 creator A5059352135 @default.
- W2079594443 creator A5076359094 @default.
- W2079594443 date "2012-12-18" @default.
- W2079594443 modified "2023-10-16" @default.
- W2079594443 title "Triptolide with Potential Medicinal Value for Diseases of the Central Nervous System" @default.
- W2079594443 cites W1908251611 @default.
- W2079594443 cites W1968787780 @default.
- W2079594443 cites W1969876249 @default.
- W2079594443 cites W1978239407 @default.
- W2079594443 cites W1991576282 @default.
- W2079594443 cites W1994342907 @default.
- W2079594443 cites W1995484755 @default.
- W2079594443 cites W2002408013 @default.
- W2079594443 cites W2002917813 @default.
- W2079594443 cites W2005264687 @default.
- W2079594443 cites W2006803867 @default.
- W2079594443 cites W2011162627 @default.
- W2079594443 cites W2016299824 @default.
- W2079594443 cites W2016777985 @default.
- W2079594443 cites W2017081112 @default.
- W2079594443 cites W2020666387 @default.
- W2079594443 cites W2021028337 @default.
- W2079594443 cites W2026582513 @default.
- W2079594443 cites W2030683871 @default.
- W2079594443 cites W2033196773 @default.
- W2079594443 cites W2034243900 @default.
- W2079594443 cites W2035101957 @default.
- W2079594443 cites W2039069312 @default.
- W2079594443 cites W2045262404 @default.
- W2079594443 cites W2052562226 @default.
- W2079594443 cites W2057359246 @default.
- W2079594443 cites W2057636545 @default.
- W2079594443 cites W2060208262 @default.
- W2079594443 cites W2062880198 @default.
- W2079594443 cites W2068287578 @default.
- W2079594443 cites W2068961116 @default.
- W2079594443 cites W2069567259 @default.
- W2079594443 cites W2073034471 @default.
- W2079594443 cites W2076304025 @default.
- W2079594443 cites W2080926431 @default.
- W2079594443 cites W2081338931 @default.
- W2079594443 cites W2084024229 @default.
- W2079594443 cites W2085760714 @default.
- W2079594443 cites W2090232581 @default.
- W2079594443 cites W2096565534 @default.
- W2079594443 cites W2110407418 @default.
- W2079594443 cites W2112710124 @default.
- W2079594443 cites W2113060512 @default.
- W2079594443 cites W2115102903 @default.
- W2079594443 cites W2115646840 @default.
- W2079594443 cites W2116854153 @default.
- W2079594443 cites W2119308919 @default.
- W2079594443 cites W2125272357 @default.
- W2079594443 cites W2127514232 @default.
- W2079594443 cites W2133569690 @default.
- W2079594443 cites W2137765815 @default.
- W2079594443 cites W2149522871 @default.
- W2079594443 cites W2157456531 @default.
- W2079594443 cites W2159821424 @default.
- W2079594443 cites W2163166029 @default.
- W2079594443 cites W2163685397 @default.
- W2079594443 cites W2170659029 @default.
- W2079594443 cites W2171431480 @default.
- W2079594443 cites W2315613727 @default.
- W2079594443 cites W2318612270 @default.
- W2079594443 cites W2324610745 @default.
- W2079594443 cites W4253714908 @default.
- W2079594443 cites W56747938 @default.
- W2079594443 cites W62603772 @default.
- W2079594443 doi "https://doi.org/10.1111/cns.12039" @default.
- W2079594443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6493469" @default.
- W2079594443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23253124" @default.
- W2079594443 hasPublicationYear "2012" @default.
- W2079594443 type Work @default.
- W2079594443 sameAs 2079594443 @default.
- W2079594443 citedByCount "68" @default.
- W2079594443 countsByYear W20795944432013 @default.
- W2079594443 countsByYear W20795944432014 @default.
- W2079594443 countsByYear W20795944432015 @default.
- W2079594443 countsByYear W20795944432016 @default.
- W2079594443 countsByYear W20795944432017 @default.
- W2079594443 countsByYear W20795944432018 @default.
- W2079594443 countsByYear W20795944432019 @default.
- W2079594443 countsByYear W20795944432020 @default.
- W2079594443 countsByYear W20795944432021 @default.
- W2079594443 countsByYear W20795944432022 @default.
- W2079594443 countsByYear W20795944432023 @default.
- W2079594443 crossrefType "journal-article" @default.
- W2079594443 hasAuthorship W2079594443A5055875257 @default.
- W2079594443 hasAuthorship W2079594443A5059352135 @default.
- W2079594443 hasAuthorship W2079594443A5076359094 @default.
- W2079594443 hasBestOaLocation W20795944431 @default.
- W2079594443 hasConcept C126322002 @default.
- W2079594443 hasConcept C142724271 @default.
- W2079594443 hasConcept C190283241 @default.