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• W2079596362 abstract "Abstract The efficacy of using an infected centers assay, employing herpes simplex virus-infected, Epstein-Barr virus-transformed lymphoblastoid cell lines (LCLs) as components, to study host cell reactivation has been explored. Herpes simplex virus type 1 (HSV-1) was shown through the infected centers assay to have detectable but varying ability to lytically infect LCLs established from chromosomal breakage syndromes or closely related genetic disorders. The rate of HSV inactivation by ultraviolet (uv) irradiation was faster in LCLs established from Cockayne's syndrome than in normal LCLs, and faster still in LCLs established from xeroderma pigmentosum. These results indicate that Cockayne's syndrome, while having what appears to be quantitatively normal levels of uv-induced DNA repair replication, shows decreased ability to host cell reactivate uv-damaged HSV. In direct contrast, X-irradiated HSV showed identical survival when assayed on normal LCLs or LCLs established from ataxia telangiectasia showing increased sensitivity to X irradiation as measured by colony formation. Through the infected centers assay, it has also been possible to demonstrate low levels of multiplicity reactivation of mutagen-damaged HSV in permanently proliferating LCLs." @default.
• W2079596362 created "2016-06-24" @default.
• W2079596362 creator A5071517768 @default.
• W2079596362 creator A5077216190 @default.
• W2079596362 date "1981-12-01" @default.
• W2079596362 modified "2023-09-24" @default.
• W2079596362 title "Host cell reactivation of uv- and X-ray-damaged herpes simplex virus by epstein-barr virus (EBV)-transformed lymphoblastoid cell lines" @default.
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• W2079596362 doi "https://doi.org/10.1016/0042-6822(81)90107-0" @default.
• W2079596362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6274084" @default.
• W2079596362 hasPublicationYear "1981" @default.
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