Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079600805> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2079600805 endingPage "426" @default.
- W2079600805 startingPage "425" @default.
- W2079600805 abstract "A Locked Nucleic Acid (LNA) monomer is a conformationally restricted nucleotide analogue with an extra 2′-O, 4′-C-methylene bridge added to the ribose ring that is known to exhibit enhanced hybridization affinity towards complementary DNA and RNA, however the underlying thermodynamic basis for this observation are poorly understood. We have evaluated the influence of LNA residues on hybridization thermodynamics, counterions and hydration of DNA•DNA and DNA•RNA heteroduplex using spectroscopic and calorimetric techniques. Thermodynamic analysis for duplex formation using UV and differential scanning calorimetry suggested that LNA-induced stabilization results from a large, favorable increase in the enthalpy of hybridization that compensates for the unfavorable entropy change. The heat capacity change, ΔCp, accompanying the duplex formation, obtained through DSC, has also been reported and has been used to furnish thermodynamic parameters at 37 °C. Furthermore, it was observed that relative to the formation of unmodified duplex, the formation of LNA-modified duplexes was accompanied by a higher uptake of counterions and a lower uptake of water molecules." @default.
- W2079600805 created "2016-06-24" @default.
- W2079600805 creator A5022524918 @default.
- W2079600805 creator A5048384135 @default.
- W2079600805 creator A5060097336 @default.
- W2079600805 creator A5084599077 @default.
- W2079600805 date "2008-09-01" @default.
- W2079600805 modified "2023-09-24" @default.
- W2079600805 title "Thermodynamic, Counterion and Hydration Effects for the Incorporation of Locked Nucleic Acid (LNA) Nucleotides in Duplex" @default.
- W2079600805 doi "https://doi.org/10.1093/nass/nrn216" @default.
- W2079600805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18776435" @default.
- W2079600805 hasPublicationYear "2008" @default.
- W2079600805 type Work @default.
- W2079600805 sameAs 2079600805 @default.
- W2079600805 citedByCount "6" @default.
- W2079600805 countsByYear W20796008052013 @default.
- W2079600805 countsByYear W20796008052017 @default.
- W2079600805 countsByYear W20796008052018 @default.
- W2079600805 crossrefType "journal-article" @default.
- W2079600805 hasAuthorship W2079600805A5022524918 @default.
- W2079600805 hasAuthorship W2079600805A5048384135 @default.
- W2079600805 hasAuthorship W2079600805A5060097336 @default.
- W2079600805 hasAuthorship W2079600805A5084599077 @default.
- W2079600805 hasBestOaLocation W20796008051 @default.
- W2079600805 hasConcept C104317684 @default.
- W2079600805 hasConcept C121332964 @default.
- W2079600805 hasConcept C12554922 @default.
- W2079600805 hasConcept C129312508 @default.
- W2079600805 hasConcept C14363569 @default.
- W2079600805 hasConcept C145148216 @default.
- W2079600805 hasConcept C166940927 @default.
- W2079600805 hasConcept C178790620 @default.
- W2079600805 hasConcept C185592680 @default.
- W2079600805 hasConcept C24107716 @default.
- W2079600805 hasConcept C3017666073 @default.
- W2079600805 hasConcept C3288061 @default.
- W2079600805 hasConcept C34814092 @default.
- W2079600805 hasConcept C39519442 @default.
- W2079600805 hasConcept C512185932 @default.
- W2079600805 hasConcept C521977710 @default.
- W2079600805 hasConcept C54871578 @default.
- W2079600805 hasConcept C552990157 @default.
- W2079600805 hasConcept C55493867 @default.
- W2079600805 hasConcept C67705224 @default.
- W2079600805 hasConcept C8010536 @default.
- W2079600805 hasConcept C86803240 @default.
- W2079600805 hasConcept C97355855 @default.
- W2079600805 hasConcept C99611785 @default.
- W2079600805 hasConceptScore W2079600805C104317684 @default.
- W2079600805 hasConceptScore W2079600805C121332964 @default.
- W2079600805 hasConceptScore W2079600805C12554922 @default.
- W2079600805 hasConceptScore W2079600805C129312508 @default.
- W2079600805 hasConceptScore W2079600805C14363569 @default.
- W2079600805 hasConceptScore W2079600805C145148216 @default.
- W2079600805 hasConceptScore W2079600805C166940927 @default.
- W2079600805 hasConceptScore W2079600805C178790620 @default.
- W2079600805 hasConceptScore W2079600805C185592680 @default.
- W2079600805 hasConceptScore W2079600805C24107716 @default.
- W2079600805 hasConceptScore W2079600805C3017666073 @default.
- W2079600805 hasConceptScore W2079600805C3288061 @default.
- W2079600805 hasConceptScore W2079600805C34814092 @default.
- W2079600805 hasConceptScore W2079600805C39519442 @default.
- W2079600805 hasConceptScore W2079600805C512185932 @default.
- W2079600805 hasConceptScore W2079600805C521977710 @default.
- W2079600805 hasConceptScore W2079600805C54871578 @default.
- W2079600805 hasConceptScore W2079600805C552990157 @default.
- W2079600805 hasConceptScore W2079600805C55493867 @default.
- W2079600805 hasConceptScore W2079600805C67705224 @default.
- W2079600805 hasConceptScore W2079600805C8010536 @default.
- W2079600805 hasConceptScore W2079600805C86803240 @default.
- W2079600805 hasConceptScore W2079600805C97355855 @default.
- W2079600805 hasConceptScore W2079600805C99611785 @default.
- W2079600805 hasIssue "1" @default.
- W2079600805 hasLocation W20796008051 @default.
- W2079600805 hasLocation W20796008052 @default.
- W2079600805 hasOpenAccess W2079600805 @default.
- W2079600805 hasPrimaryLocation W20796008051 @default.
- W2079600805 hasRelatedWork W2010934396 @default.
- W2079600805 hasRelatedWork W2051743064 @default.
- W2079600805 hasRelatedWork W2070883080 @default.
- W2079600805 hasRelatedWork W2079600805 @default.
- W2079600805 hasRelatedWork W2083839602 @default.
- W2079600805 hasRelatedWork W2155134990 @default.
- W2079600805 hasRelatedWork W2162283955 @default.
- W2079600805 hasRelatedWork W2169256371 @default.
- W2079600805 hasRelatedWork W2953208167 @default.
- W2079600805 hasRelatedWork W3024785073 @default.
- W2079600805 hasVolume "52" @default.
- W2079600805 isParatext "false" @default.
- W2079600805 isRetracted "false" @default.
- W2079600805 magId "2079600805" @default.
- W2079600805 workType "article" @default.