Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079602083> ?p ?o ?g. }
- W2079602083 endingPage "3345" @default.
- W2079602083 startingPage "3335" @default.
- W2079602083 abstract "Like penicillins, cephalosporins may cause IgE-mediated reactions such as urticaria, angioedema, and anaphylactic shock, which occur because of sensitization to determinants shared with penicillins or to unique cephalosporin haptens. In particular, side-chain structures may be responsible for selective sensitization or cross-reactivity. For this reason, individual free cephalosporins are usually employed in skin testing, in addition to the classic penicillin reagents. Cephalosporin skin tests are sensitive in diagnosing immediate hypersensitivity to these betalactams. As far as in vitro tests are concerned, IgE assays for cephalosporins, specifically sepharose-radioimmunoassays, are a potentially useful tool in evaluating immediate reactions and could be used as complementary tests. In selected cases displaying negative results in both skin tests and IgE assays, a graded challenge with the implicated cephalosporin can be performed. Cephalosporin IgE-mediated hypersensitivity may be a transient condition; therefore, allergologic exams should be repeated in patients with negative initial allergologic work-ups, including challenges. Performing allergologic tests with cephalosporins other than the culprit, as well as with penicillin reagents, allows the identification of cross-reactivity with penicillins, selective responses, or cross-reactivity among cephalosporins. In the latter group, cross-reactivity is more frequently related to R1 than to R2 side-chain recognition. In assessing the selectivity of the response, negative results in skin testing with cephalosporins other than the responsible one appear to be a reliable indicator of tolerability. Keywords: Drug allergy, anaphylactic reaction, betalactams, cephalosporins, IgE, skin testing" @default.
- W2079602083 created "2016-06-24" @default.
- W2079602083 creator A5000309776 @default.
- W2079602083 creator A5009321100 @default.
- W2079602083 creator A5040116193 @default.
- W2079602083 creator A5080444413 @default.
- W2079602083 creator A5085599584 @default.
- W2079602083 date "2006-09-01" @default.
- W2079602083 modified "2023-10-18" @default.
- W2079602083 title "IgE-Mediated Hypersensitivity to Cephalosporins" @default.
- W2079602083 cites W1834076226 @default.
- W2079602083 cites W1970021403 @default.
- W2079602083 cites W1977088304 @default.
- W2079602083 cites W1983156767 @default.
- W2079602083 cites W1983969982 @default.
- W2079602083 cites W1985426071 @default.
- W2079602083 cites W1990798615 @default.
- W2079602083 cites W1997735615 @default.
- W2079602083 cites W1999422050 @default.
- W2079602083 cites W1999836718 @default.
- W2079602083 cites W2000102343 @default.
- W2079602083 cites W2004032765 @default.
- W2079602083 cites W2005245159 @default.
- W2079602083 cites W2005251828 @default.
- W2079602083 cites W2006215766 @default.
- W2079602083 cites W2007679918 @default.
- W2079602083 cites W2010444327 @default.
- W2079602083 cites W2026582524 @default.
- W2079602083 cites W2031326453 @default.
- W2079602083 cites W2032374201 @default.
- W2079602083 cites W2038175224 @default.
- W2079602083 cites W2042715670 @default.
- W2079602083 cites W2048852491 @default.
- W2079602083 cites W2049942972 @default.
- W2079602083 cites W2062135158 @default.
- W2079602083 cites W2073704218 @default.
- W2079602083 cites W2073751032 @default.
- W2079602083 cites W2077396043 @default.
- W2079602083 cites W2078456401 @default.
- W2079602083 cites W2086107563 @default.
- W2079602083 cites W2089908113 @default.
- W2079602083 cites W2091884920 @default.
- W2079602083 cites W2094320143 @default.
- W2079602083 cites W2095136329 @default.
- W2079602083 cites W2107884181 @default.
- W2079602083 cites W2111840635 @default.
- W2079602083 cites W2112326346 @default.
- W2079602083 cites W2127412099 @default.
- W2079602083 cites W2130733066 @default.
- W2079602083 cites W2146797844 @default.
- W2079602083 cites W2148568180 @default.
- W2079602083 cites W2405241300 @default.
- W2079602083 cites W59590514 @default.
- W2079602083 cites W2567175675 @default.
- W2079602083 doi "https://doi.org/10.2174/138161206778194060" @default.
- W2079602083 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17017928" @default.
- W2079602083 hasPublicationYear "2006" @default.
- W2079602083 type Work @default.
- W2079602083 sameAs 2079602083 @default.
- W2079602083 citedByCount "32" @default.
- W2079602083 countsByYear W20796020832012 @default.
- W2079602083 countsByYear W20796020832013 @default.
- W2079602083 countsByYear W20796020832014 @default.
- W2079602083 countsByYear W20796020832015 @default.
- W2079602083 countsByYear W20796020832016 @default.
- W2079602083 countsByYear W20796020832018 @default.
- W2079602083 countsByYear W20796020832019 @default.
- W2079602083 countsByYear W20796020832020 @default.
- W2079602083 countsByYear W20796020832021 @default.
- W2079602083 countsByYear W20796020832023 @default.
- W2079602083 crossrefType "journal-article" @default.
- W2079602083 hasAuthorship W2079602083A5000309776 @default.
- W2079602083 hasAuthorship W2079602083A5009321100 @default.
- W2079602083 hasAuthorship W2079602083A5040116193 @default.
- W2079602083 hasAuthorship W2079602083A5080444413 @default.
- W2079602083 hasAuthorship W2079602083A5085599584 @default.
- W2079602083 hasConcept C141105273 @default.
- W2079602083 hasConcept C159654299 @default.
- W2079602083 hasConcept C174802600 @default.
- W2079602083 hasConcept C203014093 @default.
- W2079602083 hasConcept C207480886 @default.
- W2079602083 hasConcept C2775933838 @default.
- W2079602083 hasConcept C2776217527 @default.
- W2079602083 hasConcept C2779060952 @default.
- W2079602083 hasConcept C2910308651 @default.
- W2079602083 hasConcept C501593827 @default.
- W2079602083 hasConcept C64778159 @default.
- W2079602083 hasConcept C71924100 @default.
- W2079602083 hasConcept C86803240 @default.
- W2079602083 hasConcept C89423630 @default.
- W2079602083 hasConceptScore W2079602083C141105273 @default.
- W2079602083 hasConceptScore W2079602083C159654299 @default.
- W2079602083 hasConceptScore W2079602083C174802600 @default.
- W2079602083 hasConceptScore W2079602083C203014093 @default.
- W2079602083 hasConceptScore W2079602083C207480886 @default.
- W2079602083 hasConceptScore W2079602083C2775933838 @default.
- W2079602083 hasConceptScore W2079602083C2776217527 @default.
- W2079602083 hasConceptScore W2079602083C2779060952 @default.