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- W2079602667 abstract "Electroencephalographic (EEG) electrodes and ventricular cannulae were implnated in 8 rabbits and 12 rabbits. Two anti-cholinergic agents, atropine sulfate and scopolamine hydrobromide, were given systematically (1–50 mg/kg) and intraventricular (5–800 μg). Systematic but not intraventricular injections blocked sensory stimulation-induced or eserine-induced neocortical desynchronization and hippocampal RSA in rats and rabbits which were immobile and either undrugged or ethanol intoxicated. Systemic injections also blocked hippocampal RSA but not neocortical desynchronization in rats given sensory stimulation under urethane anaesthesia, while intraventricular injections only reduced RSA amplitude. Neither systemic nor intraventricular injections blocked neocortical desynchronization or hippocampal RSA recorded from animals when they walked in a motor driven wheel. These experiments support the hypothesis that there are two types of neocortical desynchronization and hippocampal RSA, one cholinergic and one-cholinergic. They also suggest that atropine and scopolamine pass more readily to the neural system responsible for cholinergic EEG activity from the capillary bed than from the ventricular fluid." @default.
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- W2079602667 date "1976-09-01" @default.
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- W2079602667 title "Intraventricular anti-cholinergics do not block cholinergic hippocampal RSA or neocortical desynchronization in the rabbit or rat" @default.
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- W2079602667 doi "https://doi.org/10.1016/0091-3057(76)90079-4" @default.
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