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• W2079603002 abstract "Sequence-specific binding of divalent cations to nucleosomal DNA can potentially influence nucleosome position and mobility, as well as modulate interactions with nuclear factors. We define the bonding and specificity of divalent cation interaction with nucleosomal DNA by characterizing Mn2+ binding in the x-ray structure of the nucleosome core particle at 1.9-A resolution. Manganese ions are found ligated with high occupancy in the major groove to 12 of 22 GG and GC base pair steps. The specific location and mode of metal binding is the consequence of unambiguous conformational differences between dinucleotide sites, owing to their sequence context and orientation in the nucleosome core." @default.
• W2079603002 created "2016-06-24" @default.
• W2079603002 creator A5056408566 @default.
• W2079603002 creator A5069300641 @default.
• W2079603002 date "2002-08-08" @default.
• W2079603002 modified "2023-10-02" @default.
• W2079603002 title "DNA-dependent divalent cation binding in the nucleosome core particle" @default.
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• W2079603002 doi "https://doi.org/10.1073/pnas.172271399" @default.
• W2079603002 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/123228" @default.
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