FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2079604041> ?p ?o ?g. }

• W2079604041 endingPage "685" @default.
• W2079604041 startingPage "671" @default.
• W2079604041 abstract "In this study, we used a well-established animal model to investigate changes in the peptidergic and parasympathetic innervation of the bladder following chronic bladder inflammation. Adult female Sprague–Dawley rats were injected with either 70mg/kg cyclophosphamide diluted in saline, i.p., once every 3 days or saline. After 10 days, all animals were tested for urinary frequency and number of low volume voids, as well as symptoms of spontaneous pain. At the end of 12 days, all animals were perfused with histological fixatives and the urinary bladders processed for immunofluorescence using antibodies against calcitonin gene-related peptide and the vesicular acetylcholine transporter as markers, respectively, of peptidergic primary afferent fibers and parasympathetic efferent fibers. We show that animals treated with cyclophosphamide had inflamed bladders and displayed high urinary frequency as well as some indicators of spontaneous pain, such as piloerection and a rounded-back posture. Furthermore, they had a significant increase in the density of both parasympathetic and peptidergic sensory fibers in the bladder mucosa and an increase in peptidergic sensory fibers in the detrusor muscle. Based on these results, we suggest that peripheral sprouting of parasympathetic and peptidergic fibers could be a mechanism responsible for sensitization of the bladder, leading to urinary symptoms. Since we observed that the parasympathetic and peptidergic fibers often wrapped around one another and that their varicosities were very close, these two fiber populations may be interacting with each other to lead to and maintain sensitization. Future studies are required to establish the role of this fiber sprouting in bladder symptoms." @default.
• W2079604041 created "2016-06-24" @default.
• W2079604041 creator A5004443616 @default.
• W2079604041 creator A5021008820 @default.
• W2079604041 creator A5042755093 @default.
• W2079604041 date "2006-01-01" @default.
• W2079604041 modified "2023-10-16" @default.
• W2079604041 title "Peptidergic sensory and parasympathetic fiber sprouting in the mucosa of the rat urinary bladder in a chronic model of cyclophosphamide-induced cystitis" @default.
• W2079604041 cites W1511198581 @default.
• W2079604041 cites W1543054575 @default.
• W2079604041 cites W1561891673 @default.
• W2079604041 cites W1583258274 @default.
• W2079604041 cites W1964573414 @default.
• W2079604041 cites W1965764018 @default.
• W2079604041 cites W1968926525 @default.
• W2079604041 cites W1971566600 @default.
• W2079604041 cites W1972549815 @default.
• W2079604041 cites W1973959787 @default.
• W2079604041 cites W1976686989 @default.
• W2079604041 cites W1980825319 @default.
• W2079604041 cites W1984510719 @default.
• W2079604041 cites W1989752448 @default.
• W2079604041 cites W1990006755 @default.
• W2079604041 cites W1992296810 @default.
• W2079604041 cites W1995110348 @default.
• W2079604041 cites W1996793931 @default.
• W2079604041 cites W1997629062 @default.
• W2079604041 cites W2008446688 @default.
• W2079604041 cites W2009336765 @default.
• W2079604041 cites W2015638728 @default.
• W2079604041 cites W2024424546 @default.
• W2079604041 cites W2026288049 @default.
• W2079604041 cites W2027735589 @default.
• W2079604041 cites W2038657774 @default.
• W2079604041 cites W2039458288 @default.
• W2079604041 cites W2047691988 @default.
• W2079604041 cites W2057198000 @default.
• W2079604041 cites W2059034808 @default.
• W2079604041 cites W2064331471 @default.
• W2079604041 cites W2066004393 @default.
• W2079604041 cites W2066803728 @default.
• W2079604041 cites W2068146214 @default.
• W2079604041 cites W2072753218 @default.
• W2079604041 cites W2079741969 @default.
• W2079604041 cites W2083484726 @default.
• W2079604041 cites W2086237898 @default.
• W2079604041 cites W2088418950 @default.
• W2079604041 cites W2108836444 @default.
• W2079604041 cites W2121405720 @default.
• W2079604041 cites W2123649763 @default.
• W2079604041 cites W2126622242 @default.
• W2079604041 cites W2130980764 @default.
• W2079604041 cites W2131166849 @default.
• W2079604041 cites W2154105016 @default.
• W2079604041 cites W2410167918 @default.
• W2079604041 cites W2412671723 @default.
• W2079604041 cites W3022086483 @default.
• W2079604041 cites W4246253704 @default.
• W2079604041 doi "https://doi.org/10.1016/j.neuroscience.2005.11.050" @default.
• W2079604041 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16989017" @default.
• W2079604041 hasPublicationYear "2006" @default.
• W2079604041 type Work @default.
• W2079604041 sameAs 2079604041 @default.
• W2079604041 citedByCount "23" @default.
• W2079604041 countsByYear W20796040412013 @default.
• W2079604041 countsByYear W20796040412015 @default.
• W2079604041 countsByYear W20796040412016 @default.
• W2079604041 countsByYear W20796040412018 @default.
• W2079604041 countsByYear W20796040412020 @default.
• W2079604041 countsByYear W20796040412021 @default.
• W2079604041 countsByYear W20796040412022 @default.
• W2079604041 crossrefType "journal-article" @default.
• W2079604041 hasAuthorship W2079604041A5004443616 @default.
• W2079604041 hasAuthorship W2079604041A5021008820 @default.
• W2079604041 hasAuthorship W2079604041A5042755093 @default.
• W2079604041 hasConcept C118303440 @default.
• W2079604041 hasConcept C126322002 @default.
• W2079604041 hasConcept C134018914 @default.
• W2079604041 hasConcept C142724271 @default.
• W2079604041 hasConcept C163170386 @default.
• W2079604041 hasConcept C170493617 @default.
• W2079604041 hasConcept C204787440 @default.
• W2079604041 hasConcept C2775910092 @default.
• W2079604041 hasConcept C2776512019 @default.
• W2079604041 hasConcept C2777540882 @default.
• W2079604041 hasConcept C2778508898 @default.
• W2079604041 hasConcept C2778941218 @default.
• W2079604041 hasConcept C2779263132 @default.
• W2079604041 hasConcept C2779762690 @default.
• W2079604041 hasConcept C71924100 @default.
• W2079604041 hasConcept C77411442 @default.
• W2079604041 hasConceptScore W2079604041C118303440 @default.
• W2079604041 hasConceptScore W2079604041C126322002 @default.
• W2079604041 hasConceptScore W2079604041C134018914 @default.
• W2079604041 hasConceptScore W2079604041C142724271 @default.
• W2079604041 hasConceptScore W2079604041C163170386 @default.
• W2079604041 hasConceptScore W2079604041C170493617 @default.
• W2079604041 hasConceptScore W2079604041C204787440 @default.

• next